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  1. 学位論文
  2. 歯学研究科
  3. 平成27年度
  4. 課程博士

VEGF Expression in Diabetic Rats Promotes Alveolar Bone Resorption by Porphyromonas gingivalis LPS

https://osaka-dent.repo.nii.ac.jp/records/107
https://osaka-dent.repo.nii.ac.jp/records/107
cddd0f45-491c-4cbd-a07d-2999043aeec0
名前 / ファイル ライセンス アクション
kou_771_txt.pdf 学位論文 (6.8 MB)
kou_771.pdf 論文内容要旨・審査結果要旨 (214.2 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2016-08-01
本文言語
言語 eng
タイトル
タイトル VEGF Expression in Diabetic Rats Promotes Alveolar Bone Resorption by Porphyromonas gingivalis LPS
著者 津守, 紀昌

× 津守, 紀昌

津守, 紀昌

ja-Kana ツモリ, ノリマサ

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Tsumori, Norimasa

× Tsumori, Norimasa

en Tsumori, Norimasa

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キーワード
主題Scheme Other
主題 Bone resorption
キーワード
主題Scheme Other
主題 Diabete mellitus
キーワード
主題Scheme Other
主題 Osteoclast
キーワード
主題Scheme Other
主題 P.g LPS
キーワード
主題Scheme Other
主題 VEGF
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_db06
資源タイプ doctoral thesis
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
抄録
内容記述タイプ Abstract
内容記述 Diabetes mellitus is an important risk factor for periodontitis. Although numerous complications are associated with the disease, all of these are attributed to vascular disorders and are closely related to the potent angiogeneic factor vascular endothelial growth factor (VEGF). However, it remains unknown how diabetes mellitus/hyperglycemia-associated VEGF expression affects alveolar bone resorption in the periodontium. The aim of this study was to determine the level of adverse effect on bone resorption of diabetes mellitus-associated VEGF. Therefore, we induced experimental periodontitis with injections of the endotoxin lipopolysaccharide (LPS) from Porphyromonas gingivalis in diabetic rats, measured the level of bone resorption, and observed VEGF expression and localization of osteoclasts in the periodontium. Eight-week-old male Goto-Kakizaki (GK) rats were in the experimental group, and male Wistar rats were in the control group. Experimental periodontitis was induced by injecting P. gingivalis LPS and inserting ligatures. All rats were euthanized and underwent micro X-ray computed tomography (CT) to acquire bone resorption image, in which the distance between the cement–enamel junction and the alveolar bone crest was measured to determine the amount of bone resorption. Samples were prepared and underwent immunohistochemical staining with an anti-VEGF monoclonal antibody and tartrate-resistant acid phosphatase (TRAP) staining. The amount of bone resorption measured by micro X-ray CT images was significantly greater in the experimental group than in the control group. Immunohistochemical staining showed that VEGF expression levels on the alveolar bone surface and around microvessels in the gingival connective tissue were higher in the experimental group than in the control group. On the alveolar bone surface, localization of TRAP-positive cells and bone resorption lacunae from the same sites were observed in both groups. These results suggest that VEGF expression in the periodontium caused by hyperglycemia in rats with diabetes mellitus affects P. gingivalis LPS-induced alveolar bone resorption.
学位名
学位名 博士(歯学)
学位授与機関
学位授与機関識別子Scheme kakenhi
学位授与機関識別子 34408
学位授与機関名 大阪歯科大学
学位授与年月日
学位授与年月日 2016-03-11
学位授与番号
学位授与番号 甲第771号
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