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Porous Alpha-Tricalcium Phosphate with Immobilized Basic Fibroblast Growth Factor Enhances Bone Regeneration in a Canine Mandibular Bone Defect Model
https://osaka-dent.repo.nii.ac.jp/records/156
https://osaka-dent.repo.nii.ac.jp/records/156e99e6cc7-73bc-476a-bea4-3f0704529241
名前 / ファイル | ライセンス | アクション |
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学位論文 (3.6 MB)
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論文内容要旨・審査結果要旨 (233.3 kB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2017-04-19 | |||||
本文言語 | ||||||
言語 | eng | |||||
タイトル | ||||||
タイトル | Porous Alpha-Tricalcium Phosphate with Immobilized Basic Fibroblast Growth Factor Enhances Bone Regeneration in a Canine Mandibular Bone Defect Model | |||||
著者 |
小林, 信博
× 小林, 信博 |
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キーワード | ||||||
主題Scheme | Other | |||||
主題 | alpha-tricalcium phosphate |basic fibroblast growth factor | bone regeneration | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
資源タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The effect of porous alpha-tricalcium phosphate (-TCP) with immobilized basic fibroblast growth factor (bFGF) on bone regeneration was evaluated in a canine mandibular bone defect model. Identical bone defects were made in the canine mandible; six defects in each animal were filled with porous α-TCP with bFGF bound via heparin (bFGF group), whereas the other was filled with unmodified porous α-TCP (control group). Micro-computed tomography and histological evaluation were performed 2, 4, and 8 weeks after implantation. The bone mineral density of the bFGF group was higher than that of the control group at each time point (P < 0.05), and the bone mineral content of the bFGF group was higher than that of the control group at 4 and 8 weeks (P < 0.05). Histological evaluation 2 weeks after implantation revealed that the porous -TCP had degraded and bone had formed on the surface of -TCP particles in the bFGF group. At 8 weeks, continuous cortical bone with a Haversian structure covered the top of bone defects in the bFGF group. These findings demonstrate that porous -TCP with immobilized bFGF can promote bone regeneration. | |||||
学位名 | ||||||
学位名 | 博士(歯学) | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 34408 | |||||
学位授与機関名 | 大阪歯科大学 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2017-03-10 | |||||
学位授与番号 | ||||||
学位授与番号 | 甲第798号 |