{"created":"2023-05-15T13:57:27.091252+00:00","id":153,"links":{},"metadata":{"_buckets":{"deposit":"50e7c61c-e64b-425a-a668-7417eda7025b"},"_deposit":{"created_by":16,"id":"153","owners":[16],"pid":{"revision_id":0,"type":"depid","value":"153"},"status":"published"},"_oai":{"id":"oai:osaka-dent.repo.nii.ac.jp:00000153","sets":["1686642104765:1:16:17"]},"author_link":["522","521"],"item_10006_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"破骨細胞形成とp38 MAP kinase経路に対するGallotanninの影響"}]},"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2017-03-10"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"大阪歯科大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"34408","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）"}]},"item_10006_description_10":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_description":"2016年度","subitem_description_type":"Other"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We examined the effect of gallotannin on osteoclast differentiation in vitro. We found that gallotannin suppressed osteoclast differentiation in a bone marrow culture system stimulated with 1, 25 (OH)2 D3, as well as in a M-CSF/RANKL-treated BMM culture system. Also, we found that gallotannin treatment suppressed the expression of NFATc1 in RANKL-treated BMMs. To further elucidate the mechanisms underlying the suppressive effect of gallotannin on osteoclast differentiation, we examined the effects of gallotannin on RANKL- and M-CSF-mediated intracellular signaling. Although gallotannin did not affect the activation kinetics of ERK1/2 and Akt, it blunted p38 MAPK activation in RANKL-treated BMMs. We also observed the suppressive effects of gallotannin on M-CSF-induced p38 MAPK activation in BMMs that had been programmed for osteoclast differentiation by pretreatment with RANKL and low-dose M-CSF for 24 h. In other words, gallotannin specifically suppressed RANKL- and M-CSF-induced activation of the p-38 MAPK pathway. ","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第795号"}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"細山, 有規子"},{"creatorName":"ホソヤマ, ユキコ ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"521","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hosoyama, Yukiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"522","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-04-20"}],"displaytype":"detail","filename":"kou_795_txt_Joint.pdf","filesize":[{"value":"2.3 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"学位論文","url":"https://osaka-dent.repo.nii.ac.jp/record/153/files/kou_795_txt_Joint.pdf"},"version_id":"b99f7f08-4ff6-4d99-b5ce-a1da7490b875"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-04-19"}],"displaytype":"detail","filename":"kou_795.pdf","filesize":[{"value":"179.8 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"論文内容要旨・審査結果要旨","url":"https://osaka-dent.repo.nii.ac.jp/record/153/files/kou_795.pdf"},"version_id":"bfef5da4-374b-4ea3-9d22-9e9a53c679b0"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Osteoclast｜Gallotannin｜Tannin｜p38 MAP kinase｜NFATc1","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Effects of gallotannin on osteoclastogenesis and the p38 MAP kinase pathway","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effects of gallotannin on osteoclastogenesis and the p38 MAP kinase pathway"}]},"item_type_id":"10006","owner":"16","path":["17"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-04-19"},"publish_date":"2017-04-19","publish_status":"0","recid":"153","relation_version_is_last":true,"title":["Effects of gallotannin on osteoclastogenesis and the p38 MAP kinase pathway"],"weko_creator_id":"16","weko_shared_id":-1},"updated":"2023-05-15T14:18:37.833067+00:00"}