@phdthesis{oai:osaka-dent.repo.nii.ac.jp:00000156,
 author = {小林, 信博},
 month = {2017-09-21, 2017-04-19},
 note = {The effect of porous alpha-tricalcium phosphate (-TCP) with immobilized basic fibroblast growth factor (bFGF) on bone regeneration was evaluated in a canine mandibular bone defect model. Identical bone defects were made in the canine mandible; six defects in each animal were filled with porous α-TCP with bFGF bound via heparin (bFGF group), whereas the other was filled with unmodified porous α-TCP (control group). Micro-computed tomography and histological evaluation were performed 2, 4, and 8 weeks after implantation. The bone mineral density of the bFGF group was higher than that of the control group at each time point (P < 0.05), and the bone mineral content of the bFGF group was higher than that of the control group at 4 and 8 weeks (P < 0.05). Histological evaluation 2 weeks after implantation revealed that the porous -TCP had degraded and bone had formed on the surface of -TCP particles in the bFGF group. At 8 weeks, continuous cortical bone with a Haversian structure covered the top of bone defects in the bFGF group. These findings demonstrate that porous -TCP with immobilized bFGF can promote bone regeneration.},
 school = {大阪歯科大学},
 title = {Porous Alpha-Tricalcium Phosphate with Immobilized Basic Fibroblast Growth Factor Enhances Bone Regeneration in a Canine Mandibular Bone Defect Model},
 year = {},
 yomi = {こばやし, のぶひろ}
}