{"created":"2023-05-15T13:57:27.447101+00:00","id":160,"links":{},"metadata":{"_buckets":{"deposit":"c23ca91e-ec5b-43ab-b716-e8f701a2abf5"},"_deposit":{"created_by":16,"id":"160","owners":[16],"pid":{"revision_id":0,"type":"depid","value":"160"},"status":"published"},"_oai":{"id":"oai:osaka-dent.repo.nii.ac.jp:00000160","sets":["1686642104765:1:16:17"]},"author_link":["532"],"item_10006_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"エナメル上皮腫における上皮間葉転写因子 Snail, Slug, Twist, TGF-β, E-cadherin の発現"}]},"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2017-03-10"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"大阪歯科大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"34408","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）"}]},"item_10006_description_10":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_description":"2016年度","subitem_description_type":"Other"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Epithelial mesenchymal transition (EMT), the transition of epithelial cells into motile mesenchymal cells,plays an important role in embryogenesis, cancer invasion,and metastasis. Ameloblastomas are common epithelial\nodontogenic tumors, occurring exclusively in the mandible with locally invasive growth. Thirty-seven ameloblastoma cases were evaluated for the involvement of EMT by immunohistochemical staining and western blotting using antibodies against Slug, Snail, Twist, TGF-b, and E-cadherin. Double immunostaining was also performed. Slug and TGF-b were expressed in the nuclei of peripheral and stellate reticulum cells of ameloblastoma nests. Twenty cases of Snail, 36 of Slug, 8 of Twist, and 19 of TGF-b showed strong expression in tumor cells in follicular and plexiform patterns. Expression of Slug and TGF-b increased in regions where the expression of E-cadherin was reduced. EMT was found to be associated with the\nlocal invasive growth of ameloblastoma. These data suggest that reduced expression of E-cadherin and over-expression of Slug, Snail, and TGF-b induce EMT. Given that ameloblastomas are characterized by local invasiveness, EMT might be related to their development. Thus, strong expression of Slug and TGF-b and reduced expression of E-cadherin might be related to the local invasiveness of ameloblastoma.","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第802号"}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"栗岡, 香美"},{"creatorName":"クリオカ, カガミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"532","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-12-20"}],"displaytype":"detail","filename":"kou_802_txt.pdf","filesize":[{"value":"1.6 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"学位論文","url":"https://osaka-dent.repo.nii.ac.jp/record/160/files/kou_802_txt.pdf"},"version_id":"10be35c1-ac1d-4034-9ecd-f43b6103e837"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-17"}],"displaytype":"detail","filename":"kou_802.pdf","filesize":[{"value":"207.0 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"論文内容要旨・審査結果要旨","url":"https://osaka-dent.repo.nii.ac.jp/record/160/files/kou_802.pdf"},"version_id":"b9537aed-eb20-41ac-851b-7a3ff54ec5eb"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Epithelial mesenchymal transition (EMT)","subitem_subject_scheme":"Other"},{"subitem_subject":"Ameloblastoma","subitem_subject_scheme":"Other"},{"subitem_subject":"Immunohistochemistry","subitem_subject_scheme":"Other"},{"subitem_subject":"Double immunostaining","subitem_subject_scheme":"Other"},{"subitem_subject":"Snail","subitem_subject_scheme":"Other"},{"subitem_subject":"Slug","subitem_subject_scheme":"Other"},{"subitem_subject":"E-cadherin","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Differential expression of the epithelial mesenchymal transition factors Snail, Slug, Twist, TGF-β, and E-cadherin in ameloblastoma","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Differential expression of the epithelial mesenchymal transition factors Snail, Slug, Twist, TGF-β, and E-cadherin in ameloblastoma"}]},"item_type_id":"10006","owner":"16","path":["17"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-04-19"},"publish_date":"2017-04-19","publish_status":"0","recid":"160","relation_version_is_last":true,"title":["Differential expression of the epithelial mesenchymal transition factors Snail, Slug, Twist, TGF-β, and E-cadherin in ameloblastoma"],"weko_creator_id":"16","weko_shared_id":-1},"updated":"2023-05-15T14:17:19.285770+00:00"}