{"created":"2023-05-15T13:57:27.772516+00:00","id":165,"links":{},"metadata":{"_buckets":{"deposit":"cd560e38-88e9-4864-869f-9207058eb3d3"},"_deposit":{"created_by":16,"id":"165","owners":[16],"pid":{"revision_id":0,"type":"depid","value":"165"},"status":"published"},"_oai":{"id":"oai:osaka-dent.repo.nii.ac.jp:00000165","sets":["1686642104765:1:16:17"]},"author_link":["540"],"item_10006_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"マウス顎下腺発生過程における転写因子 Grhl2 とその標的遺伝子の発現"}]},"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2017-03-10"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"大阪歯科大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"34408","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）"}]},"item_10006_description_10":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_description":"2016年度","subitem_description_type":"Other"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Development of the salivary gland is characterized by extensive branching morphogenesis and lumen formation as well as differentiation into acinar and ductal cells. Although various molecules have been implicated in salivary gland development, transcription factors regulating the expression of those molecules and salivary gland development are largely unknown. The GRHL2 transcription factor and its target gene product SPINT1 as well as the SPINT1-regualted protease matriptase play crucial roles in epithelial development in several organs. Here we examined the expression of these epithelial regulators in developing mouse SMG. Of the three Grhl gene members, Grhl2 was the most abundant in embryonic SMG. The expression levels of GRHL2, SPINT1 and matriptase were increased during development of the gland. All of these molecules were expressed exclusively in the epithelial tissue. The present data may suggest the involvement of these molecules in SMG development and give a clue to developing a regenerative therapy of damaged salivary glands.","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第807号"}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"松下, 巧"},{"creatorName":"マツシタ, タクミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"540","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-08-17"}],"displaytype":"detail","filename":"kou_807_txt.pdf","filesize":[{"value":"889.4 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"学位論文","url":"https://osaka-dent.repo.nii.ac.jp/record/165/files/kou_807_txt.pdf"},"version_id":"2357479f-6285-47e7-af43-e5f87887e03b"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-04-19"}],"displaytype":"detail","filename":"kou_807.pdf","filesize":[{"value":"171.5 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"論文内容要旨・審査結果要旨","url":"https://osaka-dent.repo.nii.ac.jp/record/165/files/kou_807.pdf"},"version_id":"cf946c9c-e01c-4354-a974-2e1b32db2fcd"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Grhl2","subitem_subject_scheme":"Other"},{"subitem_subject":"SPINT1","subitem_subject_scheme":"Other"},{"subitem_subject":"Matriptase","subitem_subject_scheme":"Other"},{"subitem_subject":"Salivary gland","subitem_subject_scheme":"Other"},{"subitem_subject":"Development","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Expression of Grhl2 and Its Target Gene Products in Developing Mouse Submandibular Gland","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Expression of Grhl2 and Its Target Gene Products in Developing Mouse Submandibular Gland"}]},"item_type_id":"10006","owner":"16","path":["17"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-04-19"},"publish_date":"2017-04-19","publish_status":"0","recid":"165","relation_version_is_last":true,"title":["Expression of Grhl2 and Its Target Gene Products in Developing Mouse Submandibular Gland"],"weko_creator_id":"16","weko_shared_id":-1},"updated":"2023-05-15T14:16:35.704391+00:00"}