{"created":"2023-05-15T13:57:21.130382+00:00","id":17,"links":{},"metadata":{"_buckets":{"deposit":"5d43b244-e923-408c-bfa4-3b8c33900619"},"_deposit":{"created_by":14,"id":"17","owners":[14],"pid":{"revision_id":0,"type":"depid","value":"17"},"status":"published"},"_oai":{"id":"oai:osaka-dent.repo.nii.ac.jp:00000017","sets":["1686642104765:1:6:8"]},"author_link":["31","386"],"item_10006_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"マウス⾻髄由来細胞と⾻芽細胞の共培養系でのヒアルロン酸の破⾻細胞分化に及ぼす影響"}]},"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2015-03-06"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"大阪歯科大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"34408","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）"}]},"item_10006_description_10":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_description":"2014年度","subitem_description_type":"Other"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Hyaluronan (HA) is widely used as a disease-modifying drug to reduce pain in patients with osteoarthritis. We investigated whether the commercially available HA product Artz^[○!R] contributes to bone regeneration. To assess whether exogenous HA influences bone resorption and formation, we examined osteoclast differentiation in mouse bone marrow-derived cells co- cultured with primary mouse calvarial osteoblasts, and also analyzed the proliferation and adhesion of these cells. Coculture of osteoblasts and bone marrow cells in the presence of HA resulted in decreased osteoclast differentiation. Cellular proliferation of osteoblasts and bone marrow cells in the presence of HA was significantly greater than in the absence of HA. However, adhesion of bone marrow cells was decreased by HA. The increased proliferation of osteoblasts and decreased number of attached bone marrow cells in the presence of HA lead to an imbalance between the number of these cells, resulting in suppressed osteoclast differentiation.","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第751号"}]},"item_10006_publisher_5":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"大阪歯科学会"}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"廣⽥, 秀逸"},{"creatorName":"ヒロタ, シュウイツ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"386","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hirota, Shuitsu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"31","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-08-01"}],"displaytype":"detail","filename":"kou_751_txt..pdf","filesize":[{"value":"322.4 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"学位論文","url":"https://osaka-dent.repo.nii.ac.jp/record/17/files/kou_751_txt..pdf"},"version_id":"a66784ee-5dd9-430c-acdc-78105b267d6f"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-08-01"}],"displaytype":"detail","filename":"kou_751.pdf","filesize":[{"value":"180.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"論文内容要旨・審査結果要旨","url":"https://osaka-dent.repo.nii.ac.jp/record/17/files/kou_751.pdf"},"version_id":"f6c2dc30-b690-4742-8c74-d0d0c13c85da"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Hyaluronan","subitem_subject_scheme":"Other"},{"subitem_subject":"Coculture","subitem_subject_scheme":"Other"},{"subitem_subject":"Osteoclast differentiation","subitem_subject_scheme":"Other"},{"subitem_subject":"Hyaluronan","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Coculture","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Osteoclast differentiation","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Effect of hyaluronan on osteoclast differentiation in mouse bone marrow-derived cells cocultured with primary osteoblasts","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effect of hyaluronan on osteoclast differentiation in mouse bone marrow-derived cells cocultured with primary osteoblasts"}]},"item_type_id":"10006","owner":"14","path":["8"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-08-01"},"publish_date":"2016-08-01","publish_status":"0","recid":"17","relation_version_is_last":true,"title":["Effect of hyaluronan on osteoclast differentiation in mouse bone marrow-derived cells cocultured with primary osteoblasts"],"weko_creator_id":"14","weko_shared_id":14},"updated":"2023-05-15T14:11:44.115222+00:00"}