{"created":"2023-05-15T13:57:28.338371+00:00","id":176,"links":{},"metadata":{"_buckets":{"deposit":"1f246ec2-04e6-4e4e-afb8-bc28c678f277"},"_deposit":{"created_by":16,"id":"176","owners":[16],"pid":{"revision_id":0,"type":"depid","value":"176"},"status":"published"},"_oai":{"id":"oai:osaka-dent.repo.nii.ac.jp:00000176","sets":["1686642104765:1:33:28"]},"author_link":["558"],"item_10006_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"イヌ下顎骨二壁性骨欠損モデルにおける塩基性線維芽細胞増殖因子を固定化したα-リン酸三カルシウムの歯周組織再生"}]},"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2018-03-09"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"大阪歯科大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"34408","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）"}]},"item_10006_description_10":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_description":"2017年度","subitem_description_type":"Other"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We evaluated the effect of porous alpha-tricalcium phosphate (α-TCP) with immobilized basic fibroblast growth factor (bFGF) on periodontal regeneration in a canine model of 2-wall periodontal defects. Identical bone defects were made in the canine mandible; six defects in each animal were filled with porous α-TCP with bFGF bound via heparin (bFGF group), and the remaining defects were filled with unmodified porous α-TCP (control group). Micro-computed tomography and histological evaluation were performed at 2, 4, and 8 weeks post-implantation. The bone mineral content of the bFGF group was higher than that of the control group at 2 and 4 weeks (p < 0.05). Histological evaluation at 2 weeks post-implantation revealed degradation of the porous α-TCP, and bone had formed on the surface of α-TCP particles in the bFGF group. Some of these collagen fibers connected the newly formed cementum with the alveolar bone, revealing the formation of new periodontal ligaments with Sharpey's fibers. At 8 weeks, continuous cortical bone with a Haversian structure covered the top of the bone defects in the bFGF group. These findings indicate that porous α-TCP with immobilized bFGF could promote periodontal regeneration at the early regeneration phase in a canine model of 2-wall periodontal defects.","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第814号"}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"松瀬, 和也"},{"creatorName":"マツセ, カズヤ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-12-25"}],"displaytype":"detail","filename":"kou_814_txt.pdf","filesize":[{"value":"1.3 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"学位論文","url":"https://osaka-dent.repo.nii.ac.jp/record/176/files/kou_814_txt.pdf"},"version_id":"05d70f2b-1f71-46ca-818c-f2ab7fd01de2"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-05-17"}],"displaytype":"detail","filename":"kou_814.pdf","filesize":[{"value":"226.2 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"論文内容要旨・審査結果要旨","url":"https://osaka-dent.repo.nii.ac.jp/record/176/files/kou_814.pdf"},"version_id":"7587f323-a9ca-48a5-9ef5-74e55b978e3a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Alpha-tricalcium phosphate","subitem_subject_scheme":"Other"},{"subitem_subject":"Basic fibroblast growth factor","subitem_subject_scheme":"Other"},{"subitem_subject":"Canine2-wall periodontal defect model","subitem_subject_scheme":"Other"},{"subitem_subject":"Immobilization","subitem_subject_scheme":"Other"},{"subitem_subject":"Periodontal regeneration","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Periodontal regeneration induced by porous alpha-tricalcium phosphate with immobilized basic fibroblast growth factor in a canine model of 2-wall periodontal defects","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Periodontal regeneration induced by porous alpha-tricalcium phosphate with immobilized basic fibroblast growth factor in a canine model of 2-wall periodontal defects"}]},"item_type_id":"10006","owner":"16","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-05-17"},"publish_date":"2018-05-17","publish_status":"0","recid":"176","relation_version_is_last":true,"title":["Periodontal regeneration induced by porous alpha-tricalcium phosphate with immobilized basic fibroblast growth factor in a canine model of 2-wall periodontal defects"],"weko_creator_id":"16","weko_shared_id":-1},"updated":"2023-05-15T14:25:49.882906+00:00"}