{"created":"2023-05-15T13:57:28.778253+00:00","id":184,"links":{},"metadata":{"_buckets":{"deposit":"a6435031-dc49-4957-913a-3fd8971555d1"},"_deposit":{"created_by":16,"id":"184","owners":[16],"pid":{"revision_id":0,"type":"depid","value":"184"},"status":"published"},"_oai":{"id":"oai:osaka-dent.repo.nii.ac.jp:00000184","sets":["1686642104765:1:33:28"]},"author_link":["566"],"item_10006_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"マウス脳梗塞モデルにおけるヒト脱分化脂肪細胞による機能回復"}]},"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2018-03-09"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"大阪歯科大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"34408","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）"}]},"item_10006_description_10":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_description":"2017年度","subitem_description_type":"Other"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Elderly people whose daily activities have declined due to a cerebrovascular disorder may suffer from dysphagia and may find oral hygiene difficult. Therefore, it is important to establish an effective therapy for the underlying cerebrovascular disorder. Dedifferentiated fat cells (DFAT) were obtained from mature adipocytes isolated from human buccal adipose pads in a ceiling culture. DFAT expressed the neural markers Nestin and SOX2. Flow cytometric analysis revealed that the cells had properties similar to mesenchymal stem cells. Although the transplantation of DFAT did not change the infarction area and volume ratios in a murine cerebral infarction model, functional recovery was observed in behavioral tests. Furthermore, DFAT administered to mice were later detected in cerebral infarctions. It therefore appears that transplanted DFAT affect the brain after infarction and contribute to the promotion of functional recovery. This finding may provide new cell replacement therapy options for treating disorders of the central nervous system.","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第822号"}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"覺道, 知樹"},{"creatorName":"カクドウ, トモキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-01-29"}],"displaytype":"detail","filename":"kou_822_txt.pdf","filesize":[{"value":"1.6 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"学位論文","url":"https://osaka-dent.repo.nii.ac.jp/record/184/files/kou_822_txt.pdf"},"version_id":"4cf28c0a-396a-4994-ade4-5fb6b2ba399c"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-05-17"}],"displaytype":"detail","filename":"kou_822.pdf","filesize":[{"value":"191.3 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"論文内容要旨・審査結果要旨","url":"https://osaka-dent.repo.nii.ac.jp/record/184/files/kou_822.pdf"},"version_id":"33ae16a0-b203-4b4c-847c-8ebd7952982a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Adipose stem cell","subitem_subject_scheme":"Other"},{"subitem_subject":"Cerebral infarction","subitem_subject_scheme":"Other"},{"subitem_subject":"Cerebrovascular disorder","subitem_subject_scheme":"Other"},{"subitem_subject":"Nestin","subitem_subject_scheme":"Other"},{"subitem_subject":"Neural differentiation","subitem_subject_scheme":"Other"},{"subitem_subject":"Transplantation","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Functional recovery by application of human dedifferentiated fat cells on cerebral infarction mice model","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Functional recovery by application of human dedifferentiated fat cells on cerebral infarction mice model"}]},"item_type_id":"10006","owner":"16","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-05-17"},"publish_date":"2018-05-17","publish_status":"0","recid":"184","relation_version_is_last":true,"title":["Functional recovery by application of human dedifferentiated fat cells on cerebral infarction mice model"],"weko_creator_id":"16","weko_shared_id":-1},"updated":"2023-05-15T14:23:05.370531+00:00"}