{"created":"2023-05-15T13:57:29.377920+00:00","id":196,"links":{},"metadata":{"_buckets":{"deposit":"bbce358d-2e0a-4fd6-a216-db9211292cf2"},"_deposit":{"created_by":16,"id":"196","owners":[16],"pid":{"revision_id":0,"type":"depid","value":"196"},"status":"published"},"_oai":{"id":"oai:osaka-dent.repo.nii.ac.jp:00000196","sets":["1686642104765:1:33:23"]},"author_link":["578"],"item_10006_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"IL-17 による NK92 細胞の細胞傷害能抑制機構について"}]},"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2018-03-29"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"大阪歯科大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"34408","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）"}]},"item_10006_description_10":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_description":"2017年度","subitem_description_type":"Other"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We investigated mechanisms of intracellular signaling on IL-17 stimulated NK92 cells. We confirmed that the majority of NK92 cells expressed IL-17RA. The phosphorylation of ERK and JNK were not altered in the absence or presence of IL-17. Phosphorylation of p38 was observed in the absence of IL-17, but its phosphorylation was suppressed in the presence of IL-17. There was slight phosphorylation of GSK3-β in the absence of IL-17, which was increased in the presence of IL-17. These results suggest that p38 and GSK3-β may be involved in suppressing the cytotoxicity of IL-17 stimulated NK92 cells.","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"乙第1609号"}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"足立, 哲也"},{"creatorName":"アダチ, テツヤ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"578","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-05"}],"displaytype":"detail","filename":"otu_1609.txt.pdf","filesize":[{"value":"305.4 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"学位論文","url":"https://osaka-dent.repo.nii.ac.jp/record/196/files/otu_1609.txt.pdf"},"version_id":"923750a1-d158-463e-bea4-5f7a6b7c434b"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-05-18"}],"displaytype":"detail","filename":"otu_1609.pdf","filesize":[{"value":"186.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"論文内容要旨・審査結果要旨","url":"https://osaka-dent.repo.nii.ac.jp/record/196/files/otu_1609.pdf"},"version_id":"15b70ced-c5c9-40f5-86f1-3edfd44aaa10"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"IL-17｜NK cells｜cytotoxicity","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Inhibitory mechanisms of NK92 cell cytotoxicity by IL-17 stimulation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Inhibitory mechanisms of NK92 cell cytotoxicity by IL-17 stimulation"}]},"item_type_id":"10006","owner":"16","path":["23"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-05-18"},"publish_date":"2018-05-18","publish_status":"0","recid":"196","relation_version_is_last":true,"title":["Inhibitory mechanisms of NK92 cell cytotoxicity by IL-17 stimulation"],"weko_creator_id":"16","weko_shared_id":-1},"updated":"2023-05-15T14:20:03.250105+00:00"}