{"created":"2023-09-12T02:06:40.907345+00:00","id":2000005,"links":{},"metadata":{"_buckets":{"deposit":"628b3c7f-4198-42d0-90f5-4c4ffc9a966f"},"_deposit":{"created_by":18,"id":"2000005","owner":"18","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"2000005"},"status":"published"},"_oai":{"id":"oai:osaka-dent.repo.nii.ac.jp:02000005","sets":["1686642104765:1:63:64"]},"author_link":[],"control_number":"2000005","item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2023-06-28"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"大阪歯科大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Osaka Dental University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"34408","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）","subitem_degreename_language":"ja"}]},"item_10006_description_7":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Tumor necrosis factor (TNF)-α is a major inflammatory factor that regulates tissue destruction in periodontitis and promotes the release of Matrix metalloproteinase (MMP) -1, which breaks down the gingival extracellular matrix. MMP-1 is one of the proteolytic enzymes that are capable of cleaving collagen and may play an important role in the destruction of connective tissue. The present study investigated the effects of Surface pre-reacted glass-ionomer (S-PRG) filler eluate on the secretion of MMP-1 by human gingival fibroblast (HGF) stimulated with the inflammatory cytokine TNF-α. S-PRG filler eluate did not alter Akt or nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) p65 phosphorylation levels in TNF-α-stimulated HGF. In the mitogen-activated protein kinase (MAPK) pathway, S-PRG filler eluate did not alter the phosphorylation level of p38 in TNF-α-stimulated HGF, but decreased that of c-Jun N-terminal kinase (JNK). These results will facilitate the development of new anti-inflammatory agents for periodontal disease using materials composed of S-PRG filler eluate.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"乙第1656号"}]},"item_10006_relation_14":{"attribute_name":"関連情報","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.11344/nano.14.41","subitem_relation_type_select":"DOI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"Nano Biomedicine. 2022, 14(2), p. 41-50."}]}]},"item_1694480793026":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"「論文内容要旨・審査結果要」ファイル差替（2023.10.25）"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"作成者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"蘭, 嵐","creatorNameLang":"ja"},{"creatorName":"ラン, ラン","creatorNameLang":"ja-Kana"},{"creatorName":"Lan, Lan","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-10-25"}],"filename":"otu_1656_ab_2.pdf","filesize":[{"value":"232 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"論文内容要旨・審査結果要旨","objectType":"abstract","url":"https://osaka-dent.repo.nii.ac.jp/record/2000005/files/otu_1656_ab_2.pdf"},"version_id":"44bc89ea-3bb8-4660-b063-8f98e537ffb8"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"S-PRG filler eluate","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Tumor necrosis factor-α","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Human gingival fibroblasts","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Matrix metalloproteinase","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Surface pre-reacted glass-ionomer (S-PRG) filler eluate suppresses MMP-1 secretion by TNF-α-stimulated human gingival fibroblasts","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Surface pre-reacted glass-ionomer (S-PRG) filler eluate suppresses MMP-1 secretion by TNF-α-stimulated human gingival fibroblasts","subitem_title_language":"en"},{"subitem_title":"S-PRGフィラー溶出液はTNF-α刺激ヒト歯肉線維芽細胞のMMP-1分泌を抑制する","subitem_title_language":"ja"}]},"item_type_id":"10006","owner":"18","path":["64"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-09-12"},"publish_date":"2023-09-12","publish_status":"0","recid":"2000005","relation_version_is_last":true,"title":["Surface pre-reacted glass-ionomer (S-PRG) filler eluate suppresses MMP-1 secretion by TNF-α-stimulated human gingival fibroblasts"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-10-25T03:27:40.629408+00:00"}