{"created":"2024-01-10T07:00:05.534159+00:00","id":2000048,"links":{},"metadata":{"_buckets":{"deposit":"00697047-3215-4900-914b-712907938f1e"},"_deposit":{"created_by":18,"id":"2000048","owner":"18","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"2000048"},"status":"published"},"_oai":{"id":"oai:osaka-dent.repo.nii.ac.jp:02000048","sets":["1686642104765:1:63:64"]},"author_link":[],"control_number":"2000048","item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2023-12-27"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"大阪歯科大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Osaka Dental University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"34408","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）","subitem_degreename_language":"ja"}]},"item_10006_description_7":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Nucleotide-binding oligomerization domain 1, which is constitutively expressed in human dental pulp fibroblast-like cells (hDPFs), plays a role in pulpal immune responses by sensing γ-D-glutamyl-meso-diaminopimelic acid (iE-DAP) from bacteria. Matrix metalloproteinase-1 (MMP-1) is an important enzyme that degrades type I collagen, an extracellular matrix component, and is involved in the destruction of dental pulp tissue. In the present study, we investigated the involvement of the ERK1/2 signaling pathway in MMP-1 production by iE-DAP-stimulated hDPFs. iE-DAP was not cytotoxic against hDPFs and did not affect their proliferation. A stimulation with iE-DAP enhanced MMP-1 production and ERK1/2 phosphorylation. The ERK1/2 signaling pathway was involved in the production of MMP-1 by iE-DAP-stimulated hDPFs. These results suggest that the induction of MMP-1 production by iE-DAP-stimulated hDPFs exacerbates pulpitis by promoting the degradation of surrounding collagen.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"乙第1661号"}]},"item_10006_relation_14":{"attribute_name":"関連情報","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.11344/nano.15.7","subitem_relation_type_select":"DOI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"Nano Biomedicine. 2023, (1), p. 7-13."}]}]},"item_10006_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2023 Nano Biomedical Society","subitem_rights_language":"en"},{"subitem_rights":"Creative Commons Attribution-NoDerivs 4.0 International","subitem_rights_language":"en","subitem_rights_resource":"https://creativecommons.org/licenses/by-nd/4.0/"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"作成者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"柯, 正建","creatorNameLang":"ja"},{"creatorName":"カ, セイケン","creatorNameLang":"ja-Kana"},{"creatorName":"Ke, Zhengjian","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-01-10"}],"filename":"otu_1661_ab.pdf","filesize":[{"value":"214 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"論文内容要旨・審査結果要旨","objectType":"abstract","url":"https://osaka-dent.repo.nii.ac.jp/record/2000048/files/otu_1661_ab.pdf"},"version_id":"b49009cc-43f4-49b1-ad12-866d2c143b80"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-08-27"}],"filename":"otu_1661_fulltext.pdf","filesize":[{"value":"383 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"学位論文","objectType":"fulltext","url":"https://osaka-dent.repo.nii.ac.jp/record/2000048/files/otu_1661_fulltext.pdf"},"version_id":"59056d41-01eb-4fec-9848-d26aa6a75fb8"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"γ-D-glutamyl-meso-diaminopimelic acid","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Matrix metalloproteinase-1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Human dental pulp fibroblast-like cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"γ-D-glutamyl-meso-diaminopimelic acid (iE-DAP) regulates the production of matrix metalloproteinase-1 by human dental pulp fibroblast-like cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"γ-D-glutamyl-meso-diaminopimelic acid (iE-DAP) regulates the production of matrix metalloproteinase-1 by human dental pulp fibroblast-like cells","subitem_title_language":"en"},{"subitem_title":"γ-D-グルタミル-メソ-ジアミノピメリン酸（iE-DAP）は、ヒト歯髄線維芽細胞様細胞におけるマトリックスメタロプロテイナーゼ-1産生を調節する","subitem_title_language":"ja"}]},"item_type_id":"10006","owner":"18","path":["64"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-01-10"},"publish_date":"2024-01-10","publish_status":"0","recid":"2000048","relation_version_is_last":true,"title":["γ-D-glutamyl-meso-diaminopimelic acid (iE-DAP) regulates the production of matrix metalloproteinase-1 by human dental pulp fibroblast-like cells"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-08-27T06:15:14.371707+00:00"}