{"created":"2024-01-10T07:12:11.160020+00:00","id":2000049,"links":{},"metadata":{"_buckets":{"deposit":"e5e81dfe-ad19-4b05-b41e-ea60b3450615"},"_deposit":{"created_by":18,"id":"2000049","owner":"18","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"2000049"},"status":"published"},"_oai":{"id":"oai:osaka-dent.repo.nii.ac.jp:02000049","sets":["1686642104765:1:63:64"]},"author_link":[],"control_number":"2000049","item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2023-12-27"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"大阪歯科大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Osaka Dental University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"34408","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）","subitem_degreename_language":"ja"}]},"item_10006_description_7":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Nucleotide-binding oligomerization domain 2, which is constitutively expressed in human dental pulp fibroblast-like cells (hDPFs), plays a role in pulpal immune responses by sensing muramyl dipeptide (MDP) from bacteria. Matrix metalloproteinase-3 (MMP-3) is abundantly expressed in acute pulpitis and acts as a mediator of the healing of dental pulp as an anti-inflammatory and regenerative factor. In the present study, we investigated the involvement of the ERK1/2 signaling pathway in MMP-3 production by MDP-stimulated hDPFs. MDP was not cytotoxic against hDPFs and did not affect their proliferation. A stimulation with MDP enhanced MMP-3 production and ERK1/2 phosphorylation. The ERK1/2 signaling pathway was involved in the production of MMP-3 by MDP-stimulated hDPFs. These results suggest that the induction of MMP-3 production by MDP-stimulated hDPFs has an anti-inflammatory function by degrading inflammatory cytokines.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"乙第1662号"}]},"item_10006_relation_14":{"attribute_name":"関連情報","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.11344/nano.15.14","subitem_relation_type_select":"DOI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"Nano Biomedicine. 2023, 15(1), p. 14-20."}]}]},"item_10006_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2023 Nano Biomedical Society","subitem_rights_language":"en"},{"subitem_rights":"Creative Commons Attribution-NoDerivs 4.0 International","subitem_rights_language":"en","subitem_rights_resource":"https://creativecommons.org/licenses/by-nd/4.0/"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"作成者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"閆, 揚","creatorNameLang":"ja"},{"creatorName":"エン, ヨウ","creatorNameLang":"ja-Kana"},{"creatorName":"Yan, Yang","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-01-10"}],"filename":"otu_1662_ab.pdf","filesize":[{"value":"209 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"本文内容要旨・審査結果要旨","objectType":"abstract","url":"https://osaka-dent.repo.nii.ac.jp/record/2000049/files/otu_1662_ab.pdf"},"version_id":"457f21f5-8cc7-49dd-b4d8-5cabb0dccff9"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-08-27"}],"filename":"otu_1662_fulltext.pdf","filesize":[{"value":"477 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"学位論文","objectType":"fulltext","url":"https://osaka-dent.repo.nii.ac.jp/record/2000049/files/otu_1662_fulltext.pdf"},"version_id":"dd086021-bddd-46ef-9a60-dcddd4f5fa74"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"muramyl dipeptide","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Matrix metalloproteinase-3","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Human dental pulp fibroblast-like cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Muramyl dipeptide (MDP) regulates the production of matrix metalloproteinase-3 by human dental pulp fibroblast-like cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Muramyl dipeptide (MDP) regulates the production of matrix metalloproteinase-3 by human dental pulp fibroblast-like cells","subitem_title_language":"en"},{"subitem_title":"ムラミルジペプチド（MDP）は、ヒト歯髄線維芽細胞様細胞におけるマトリックスメタロプロテイナーゼ-3の産生を調節する","subitem_title_language":"ja"}]},"item_type_id":"10006","owner":"18","path":["64"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-01-10"},"publish_date":"2024-01-10","publish_status":"0","recid":"2000049","relation_version_is_last":true,"title":["Muramyl dipeptide (MDP) regulates the production of matrix metalloproteinase-3 by human dental pulp fibroblast-like cells"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-08-27T06:21:26.513718+00:00"}