{"created":"2024-06-03T11:33:50.563035+00:00","id":2000105,"links":{},"metadata":{"_buckets":{"deposit":"579fe353-2f95-4795-84eb-8de3fd80d905"},"_deposit":{"created_by":18,"id":"2000105","owner":"18","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"2000105"},"status":"published"},"_oai":{"id":"oai:osaka-dent.repo.nii.ac.jp:02000105","sets":["1686642104765:1:63:65"]},"author_link":[],"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2024-03-01"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"大阪歯科大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Osaka Dental University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"34408","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）","subitem_degreename_language":"ja"}]},"item_10006_description_7":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Objectives: Osteosclerosis and a high bone mineral density (BMD) have been proposed as risk factors for medication-related osteonecrosis of the jaw (MRONJ). In the present study, we measured the alveolar BMD (al-BMD) of teeth indicated for extraction on dental radiographs using BMD analysis software and investigated the relationship between al-BMD and MRONJ.\nMaterials and Methods: We measured al-BMD on dental radiographs using BMD analysis software (Bone Right®) in 100 bone-modifying agent (BMA)-treated patients who visited our department for tooth extraction between November 2020 and May 2023. Fifteen patients treated with BMA for more than 4 years underwent tooth extraction 2 months after their cessation.\nResults: In 100 patients who underwent tooth extraction, only one patient on high-dose anti-resorptive agents (ARAs) developed MRONJ. al-BMD was significantly higher in MRONJ patients than in non-MRONJ patients. No significant change was observed in al-BMD before and 2 months after the cessation of BMA.\nConclusion: Patients who developed MRONJ after tooth extraction had higher al-BMD before tooth extraction, and a relationship between MRONJ and osteosclerosis cannot be ruled out. On the other hand, al-BMD did not change before and after the cessation of BMA, and MRONJ did not occur in patients treated with low-dose ARAs, suggesting that the cessation of BMA is not necessary.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第993号"}]},"item_10006_relation_14":{"attribute_name":"関連情報","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.18905/jodu.58.1_153","subitem_relation_type_select":"DOI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"Journal of Osaka Dental University. 2024, 58(1), p. 153-164."}]}]},"item_10006_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2024 The Author(s)","subitem_rights_language":"en"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"作成者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"濱田, 翔央","creatorNameLang":"ja"},{"creatorName":"ハマダ, ショウオ","creatorNameLang":"ja-Kana"},{"creatorName":"Hmada, Shoo","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-06-01"}],"filename":"kou_993_ab.pdf","filesize":[{"value":"229 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"論文内容要旨・審査結果要旨","objectType":"abstract","url":"https://osaka-dent.repo.nii.ac.jp/record/2000105/files/kou_993_ab.pdf"},"version_id":"05ccadd8-1dbf-442b-895c-cf055e4fe4a4"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2025-01-31"}],"filename":"kou_993_txt.pdf","filesize":[{"value":"1.6 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"学位論文","objectType":"fulltext","url":"https://osaka-dent.repo.nii.ac.jp/record/2000105/files/kou_993_txt.pdf"},"version_id":"cecf09ac-0a47-4417-80e7-43d133daf171"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Medication-related osteonecrosis of the jaw (MRONJ)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Alveolar bone mineral density (al-BMD)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Bone-modifying agent (BMA)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Anti-resorptive agent (ARA)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Osteoporosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Risk assessment of medication-related osteonecrosis of the jaw by alveolar bone mineral density","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Risk assessment of medication-related osteonecrosis of the jaw by alveolar bone mineral density","subitem_title_language":"en"},{"subitem_title":"歯槽骨骨密度を用いた薬剤関連顎骨壊死のリスク評価","subitem_title_language":"ja"}]},"item_type_id":"10006","owner":"18","path":["65"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-06-01"},"publish_date":"2024-06-01","publish_status":"0","recid":"2000105","relation_version_is_last":true,"title":["Risk assessment of medication-related osteonecrosis of the jaw by alveolar bone mineral density"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2025-02-02T07:27:25.997016+00:00"}