{"created":"2024-06-03T12:21:23.202180+00:00","id":2000116,"links":{},"metadata":{"_buckets":{"deposit":"c2586b16-a2d6-4041-b9df-c003d6f1116a"},"_deposit":{"created_by":18,"id":"2000116","owner":"18","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"2000116"},"status":"published"},"_oai":{"id":"oai:osaka-dent.repo.nii.ac.jp:02000116","sets":["1686642104765:1:63:65"]},"author_link":[],"control_number":"2000116","item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2024-03-01"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"大阪歯科大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Osaka Dental University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"34408","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）","subitem_degreename_language":"ja"}]},"item_10006_description_7":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"This study aimed to develop a novel culture method for rat adipose-derived stem cells(rADSC) and evaluate their osteogenic potential. The rADSC cultured in xeno-free culture medium\n(XF-rADSCs) or conventional culture medium containing fetal bovine serum (FBS-rADSCs) were com bined with micropieces of xeno-free recombinant collagen peptide to form 3-dimensional aggregates(XF-rADSC-CellSaic or FBS-rADSC-CellSaic). Both FBS-rADSC and XF-ADSC in CellSaic exhibited　multilineage differentiation potential. Compared to FBS-rADSC-CellSaic, XF-rADSC-CellSaic ac celerated and promoted osteogenic differentiation in vitro. When transplanted into rat mandibular\ncongenital bone defects, the osteogenically differentiated XF-rADSC-CellSaic induced regeneration　of bone tissue with a highly maturated structure compared to FBS-rADSC-CellSaic. In conclusion, XF-rADSC-CellSaic is a feasible 3-dimensional platform for efficient bone formation.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第1004号"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"作成者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"孫, 雨竹","creatorNameLang":"ja"},{"creatorName":"ソン, ウチク","creatorNameLang":"ja-Kana"},{"creatorName":"Sun, Yuzhu","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-06-01"}],"filename":"kou_1004_ab.pdf","filesize":[{"value":"259 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"本文内容要旨・審査結果要旨","objectType":"abstract","url":"https://osaka-dent.repo.nii.ac.jp/record/2000116/files/kou_1004_ab.pdf"},"version_id":"ef30b30f-482a-4c38-ac70-3ce52bfce6fb"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"three-dimensional scaffold","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"rat adipose-derived stem cells (rADSC)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"xeno-free culture","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"osteogenic differentiation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"rat congenital cleft-jaw model","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"bone repair","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Evaluation of Osteogenic Potential for Rat Adipose-Derived Stem Cells under Xeno-Free Environment","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Evaluation of Osteogenic Potential for Rat Adipose-Derived Stem Cells under Xeno-Free Environment","subitem_title_language":"en"},{"subitem_title":"ゼノフリー環境下におけるラット脂肪由来幹細胞の骨形成能の評価","subitem_title_language":"ja"}]},"item_type_id":"10006","owner":"18","path":["65"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-06-01"},"publish_date":"2024-06-01","publish_status":"0","recid":"2000116","relation_version_is_last":true,"title":["Evaluation of Osteogenic Potential for Rat Adipose-Derived Stem Cells under Xeno-Free Environment"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-06-07T07:13:49.838333+00:00"}