{"created":"2024-06-03T12:39:55.592001+00:00","id":2000121,"links":{},"metadata":{"_buckets":{"deposit":"cf56a1d6-b9c4-4327-a290-4eafc9b6ef02"},"_deposit":{"created_by":18,"id":"2000121","owner":"18","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"2000121"},"status":"published"},"_oai":{"id":"oai:osaka-dent.repo.nii.ac.jp:02000121","sets":["1686642104765:1:63:65"]},"author_link":[],"control_number":"2000121","item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2024-03-01"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"大阪歯科大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Osaka Dental University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"34408","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）","subitem_degreename_language":"ja"}]},"item_10006_description_7":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"In a previous study, we successfully coated hydroxyapatite (HAp) onto titanium (Ti) plates using the erbium-doped yttrium aluminum garnet pulsed-laser deposition (Er:YAG-PLD) method. In this study, we performed further experiments to validate the in vitro osteogenic properties, macrophage polarization, and in vivo osseointegration activity of HAp-coated Ti (HAp-Ti) plates and screws. Briefly, we coated a HAp film onto the surfaces of Ti plates and screws via Er:YAG-PLD. The surface morphological, elemental, and crystallographic analyses confirmed the successful surface coating. The macrophage polarization and osteogenic induction were evaluated in macrophages and rat bone marrow mesenchymal stem cells, and the in vivo osteogenic properties were studied. The results showed that needle-shaped nano-HAp promoted the early expression of osteogenic and immunogenic genes in the macrophages and induced excellent M2 polarization properties. The calcium deposition and osteocalcin production were significantly higher in the HAp-Ti than in the uncoated Ti. The implantation into rat femurs revealed that the HAp-coated materials had superior\nosteoinductive and osseointegration activities compared with the Ti, as assessed by microcomputed tomography and histology. Thus, HAp film on sandblasted Ti plates and screws via Er:YAG-PLD enhances hard-tissue differentiation, macrophage polarization, and new bone formation in tissues surrounding implants both in vitro and in vivo.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第1009号"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"作成者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"馬, 琳","creatorNameLang":"ja"},{"creatorName":"マ, リン","creatorNameLang":"ja-Kana"},{"creatorName":"Ma, Lin","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-06-01"}],"filename":"kou_1009_ab.pdf","filesize":[{"value":"331 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"本文内容要旨・審査結果要旨","objectType":"abstract","url":"https://osaka-dent.repo.nii.ac.jp/record/2000121/files/kou_1009_ab.pdf"},"version_id":"43c62450-be04-4184-aa8e-444a72affe91"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Er:YAG laser","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"pulsed-laser deposition","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"hydroxyapatite film","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"titanium implant","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"M2","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Effect of Er:YAG Pulsed Laser-Deposited Hydroxyapatite Film on Titanium Implants on M2 Macrophage Polarization in Vitro and Osteogenesis in Vivo","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effect of Er:YAG Pulsed Laser-Deposited Hydroxyapatite Film on Titanium Implants on M2 Macrophage Polarization in Vitro and Osteogenesis in Vivo","subitem_title_language":"en"},{"subitem_title":"チタンインプラント上にEr:YAGレーザーデポジション法によって成膜されたハイドロキシアパタイト膜がM2型マクロファージの分極化と骨形成に与える影響","subitem_title_language":"ja"}]},"item_type_id":"10006","owner":"18","path":["65"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-06-01"},"publish_date":"2024-06-01","publish_status":"0","recid":"2000121","relation_version_is_last":true,"title":["Effect of Er:YAG Pulsed Laser-Deposited Hydroxyapatite Film on Titanium Implants on M2 Macrophage Polarization in Vitro and Osteogenesis in Vivo"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-06-07T07:22:49.366088+00:00"}