{"created":"2024-06-03T12:46:05.672616+00:00","id":2000122,"links":{},"metadata":{"_buckets":{"deposit":"ad7c353d-d4f9-4d22-9bd0-5ee85d6b87e7"},"_deposit":{"created_by":18,"id":"2000122","owner":"18","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"2000122"},"status":"published"},"_oai":{"id":"oai:osaka-dent.repo.nii.ac.jp:02000122","sets":["1686642104765:1:63:65"]},"author_link":[],"control_number":"2000122","item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2024-03-01"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"大阪歯科大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Osaka Dental University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"34408","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）","subitem_degreename_language":"ja"}]},"item_10006_description_7":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Polyetheretherketone (PEEK) is one of the most promising implant materials for hard tissues due to its similar elastic modulus; however, usage of PEEK is still limited owing to its biological inertness and low osteoconductivity. The objective of the study was to provide PEEK with the ability to sustain the release of growth factors and the osteogenic differentiation of stem cells. The PEEK surface was sandblasted and modified with polydopamine (PDA). Moreover, successful sandblasting and PDA modification of the PEEK surface was confirmed through physicochemical characterization.\nThe gelatin hydrogel was then chemically bound to the PEEK by adding a solution of glutaraldehyde and gelatin to the surface of the PDA-modified PEEK. The binding and degradation of the gelatin hydrogel with PEEK (GPEEK) were confirmed, and the GPEEK mineralization was observed in simulated body fluid. Sustained release of bone morphogenetic protein (BMP)-2 was observed in GPEEK. When cultured on GPEEK with BMP-2, human mesenchymal stem cells (hMSCs) exhibited osteogenic differentiation. We conclude that PEEK with a gelatin hydrogel incorporating BMP-2 is a promising substrate for bone tissue engineering.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第1010号"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"作成者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"張, 若楠","creatorNameLang":"ja"},{"creatorName":"チョウ, ジャクナン","creatorNameLang":"ja-Kana"},{"creatorName":"Zhang, Ruonan","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-06-01"}],"filename":"kou_1010_ab.pdf","filesize":[{"value":"226 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"本文内容要旨・審査結果要旨","objectType":"abstract","url":"https://osaka-dent.repo.nii.ac.jp/record/2000122/files/kou_1010_ab.pdf"},"version_id":"38a183a8-6a5c-4c13-bea8-49c9e48ca8eb"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Polyetheretherketone (PEEK)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"gelatin hydrogel","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"sustained release","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"bone morphogenetic protein (BMP)-2","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"osteogenic differentiation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"bone tissue engineering","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Bioactive Polyetheretherketone with Gelatin Hydrogel Leads to Sustained Release of Bone Morphogenetic Protein-2 and Promotes Osteogenic Differentiation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Bioactive Polyetheretherketone with Gelatin Hydrogel Leads to Sustained Release of Bone Morphogenetic Protein-2 and Promotes Osteogenic Differentiation","subitem_title_language":"en"},{"subitem_title":"ゼラチンハイドロゲルを結合した生体活性ポリエーテルエーテルケトンは骨形成因子の徐放と骨分化促進をもたらす","subitem_title_language":"ja"}]},"item_type_id":"10006","owner":"18","path":["65"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-06-01"},"publish_date":"2024-06-01","publish_status":"0","recid":"2000122","relation_version_is_last":true,"title":["Bioactive Polyetheretherketone with Gelatin Hydrogel Leads to Sustained Release of Bone Morphogenetic Protein-2 and Promotes Osteogenic Differentiation"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-06-07T07:30:33.105709+00:00"}