{"created":"2024-08-27T02:46:17.871978+00:00","id":2000126,"links":{},"metadata":{"_buckets":{"deposit":"99712a9f-3568-4139-a838-9e6e57362613"},"_deposit":{"created_by":18,"id":"2000126","owner":"18","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"2000126"},"status":"published"},"_oai":{"id":"oai:osaka-dent.repo.nii.ac.jp:02000126","sets":["1686642104765:1:63:64"]},"author_link":[],"control_number":"2000126","item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2024-03-27"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"大阪歯科大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Osaka Dental University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"34408","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）","subitem_degreename_language":"ja"}]},"item_10006_description_7":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Matrix metalloproteinases degrade the extracellular matrix during remodeling, and their activity is regulated by tissue metalloproteinase inhibitors (TIMPs). Platelet-derived growth factor (PDGF) is produced in periodontal tissue and is an important regulator of wound healing and tissue repair. ERK1/2, members of the MAPK family, are intracellular signaling substance kinases involved in TIMP-1 production. To elucidate the mechanisms underlying connective tissue remodeling, the present study investigated the relationship between PDGF-bb-stimulated TIMP-1 production and ERK1/2 phosphorylation in human gingival fibroblasts (HGF). TIMP-1 production increased in a PDGF-bb concentration-dependent manner. PDGF-bb-induced increases in TIMP-1 were further enhanced by the p38α/β inhibitor SB239063 and p38α-siRNA. The PDGF-bb stimulation also induced the phosphorylation of ERK1/2. In contrast, the treatment with the p38-MAPK inhibitor SB203580 suppressed the phosphorylation of ERK1/2. These results suggest that PDGF-bb induced the production of TIMP-1 through the ERK1/2-activated signal transduction pathway in HGF. In addition, signaling cross-talk between p38α and ERK1/2 was involved in ERK1/2 activation, suggesting that ERK1/2 activation is coordinately regulated by p38α.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"乙第1664号"}]},"item_10006_relation_14":{"attribute_name":"関連情報","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.11344/nano.15.44","subitem_relation_type_select":"DOI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"Nano Biomedicine. 2023, 15(2), p. 44-50."}]}]},"item_10006_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2023 Nano Biomedical Society","subitem_rights_language":"en"},{"subitem_rights":"Creative Commons Attribution-NoDerivs 4.0 International","subitem_rights_language":"en","subitem_rights_resource":"https://creativecommons.org/licenses/by-nd/4.0/"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"作成者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"森﨑, 歩","creatorNameLang":"ja"},{"creatorName":"モリサキ, アユム","creatorNameLang":"ja-Kana"},{"creatorName":"Morisaki, Ayumu","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-06-27"}],"filename":"otu_1664_ab.pdf","filesize":[{"value":"252 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"本文内容要旨・審査結果要旨","objectType":"abstract","url":"https://osaka-dent.repo.nii.ac.jp/record/2000126/files/otu_1664_ab.pdf"},"version_id":"cd2ba41c-dbf0-409e-a219-12ff7986a676"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-08-27"}],"filename":"otu_1664_fulltext.pdf","filesize":[{"value":"527 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"学位論文","objectType":"fulltext","url":"https://osaka-dent.repo.nii.ac.jp/record/2000126/files/otu_1664_fulltext.pdf"},"version_id":"c5a4f93f-9119-4053-88e3-21e5bf31d00b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"PDGF-bb","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"TIMP-1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Human gingival fibroblasts","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Effects of Platelet-derived Growth Factor-bb on Tissue Inhibitor of Metalloproteinase-1 Production in Human Gingival-derived Fibroblasts","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effects of Platelet-derived Growth Factor-bb on Tissue Inhibitor of Metalloproteinase-1 Production in Human Gingival-derived Fibroblasts","subitem_title_language":"en"},{"subitem_title":"ヒト歯肉由来線維芽細胞のTIMP-1産生に対するPDGF-bbの影響","subitem_title_language":"ja"}]},"item_type_id":"10006","owner":"18","path":["64"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-06-27"},"publish_date":"2024-06-27","publish_status":"0","recid":"2000126","relation_version_is_last":true,"title":["Effects of Platelet-derived Growth Factor-bb on Tissue Inhibitor of Metalloproteinase-1 Production in Human Gingival-derived Fibroblasts"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-08-28T02:41:33.519076+00:00"}