{"created":"2024-08-27T03:03:25.074000+00:00","id":2000127,"links":{},"metadata":{"_buckets":{"deposit":"9626816c-623f-4134-9ed2-fca788f52fd1"},"_deposit":{"created_by":18,"id":"2000127","owner":"18","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"2000127"},"status":"published"},"_oai":{"id":"oai:osaka-dent.repo.nii.ac.jp:02000127","sets":["1686642104765:1:63:64"]},"author_link":[],"control_number":"2000127","item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2024-03-27"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"大阪歯科大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Osaka Dental University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"34408","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）","subitem_degreename_language":"ja"}]},"item_10006_description_7":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Tumor necrosis factor (TNF)-α is an inflammatory mediator that is released during the early stages of the inflammatory response and plays an important role in the development of periodontitis. Interleukin-8 (IL-8) is associated with the attraction and activation of neutrophils into the area of inflammation, which is considered an important factor in the regulation of inflammatory responses. In this study, we investigated the effect of TNF-α stimulation on IL-8 production in Ca9-22 cells, a human gingival epithelial cell line. Stimulation with TNF-α enhanced IL-8 production and ERK1/2 phosphorylation. U0126, a potent and selective MEK1/2 inhibitor, inhibited phosphorylation of ERK1/2 but not p38. These findings suggest that the enhancement of IL-8 production by TNF-α-stimulated Ca9-22 may lead to the induction and activation of neutrophils into inflamed tissues and worsen periodontitis.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"乙第1665号"}]},"item_10006_relation_14":{"attribute_name":"関連情報","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.11223/jarde.21.59","subitem_relation_type_select":"DOI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"Journal of Oral Tissue Engineering. 2023, 21(2), p. 59-65."}]}]},"item_10006_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2023 Japanese Association of Regenerative Dentistry","subitem_rights_language":"en"},{"subitem_rights":"Creative Commons Attribution-NoDerivs 4.0 International","subitem_rights_language":"en","subitem_rights_resource":"https://creativecommons.org/licenses/by-nd/4.0/"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"作成者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"鄭, 峰","creatorNameLang":"ja"},{"creatorName":"テイ, ホウ","creatorNameLang":"ja-Kana"},{"creatorName":"Zheng, Feng","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-06-27"}],"filename":"otu_1665_ab.pdf","filesize":[{"value":"235 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"論文内容要旨・審査結果要旨","objectType":"abstract","url":"https://osaka-dent.repo.nii.ac.jp/record/2000127/files/otu_1665_ab.pdf"},"version_id":"2cdbae7f-fe2f-49bb-8739-e13e307649e7"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-06-27"}],"filename":"otu_1665_fulltext.pdf","filesize":[{"value":"343 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"学位論文","objectType":"fulltext","url":"https://osaka-dent.repo.nii.ac.jp/record/2000127/files/otu_1665_fulltext.pdf"},"version_id":"43f46284-6390-4951-94c2-e5a9ed16f4e0"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"TNF-α","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"IL-8","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Human gingival epithelial cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Effects of Tumor Necrosis Factor-α on Interleukin-8 Production in Human Gingival Epithelial Cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effects of Tumor Necrosis Factor-α on Interleukin-8 Production in Human Gingival Epithelial Cells","subitem_title_language":"en"},{"subitem_title":"ヒト歯肉上皮細胞のInterleukin-8産生に対するtumor necrosis factor -αの影響","subitem_title_language":"ja"}]},"item_type_id":"10006","owner":"18","path":["64"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-06-27"},"publish_date":"2024-06-27","publish_status":"0","recid":"2000127","relation_version_is_last":true,"title":["Effects of Tumor Necrosis Factor-α on Interleukin-8 Production in Human Gingival Epithelial Cells"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-08-27T06:28:50.781110+00:00"}