{"created":"2024-08-27T03:29:04.864990+00:00","id":2000129,"links":{},"metadata":{"_buckets":{"deposit":"064855d1-cdf6-441b-b7b1-dc52311b4b1e"},"_deposit":{"created_by":18,"id":"2000129","owner":"18","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"2000129"},"status":"published"},"_oai":{"id":"oai:osaka-dent.repo.nii.ac.jp:02000129","sets":["1686642104765:1:63:64"]},"author_link":[],"control_number":"2000129","item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2024-03-27"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"大阪歯科大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Osaka Dental University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"34408","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）","subitem_degreename_language":"ja"}]},"item_10006_description_7":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"The present study attempted to obtain factors that induce the calcified nodule formation in a mesenchymal stem cell (MSC) culture through the aggregation of micro- or nanoparticles, such as calcium carbonate. There are few suitable cell sources in the oral cavity other than dental pulp tissue, from which only a small number of MSCs may be obtained. However, a large number of MSCs are needed for tooth regeneration. Therefore, factors that promote MSC proliferation and differentiation are required. Vitamin B1 (VB1), vitamin B3 (VB3) and vitamin B5 (VB5), which are present in physiologically active substances, were selected and investigated their effects to bone formation in vitro. VB1 and VB3 significantly increased the ability of dexamethasone (Dex) to form calcified nodule aggregates in vitro, whereas VB5 exerted the opposite effects. Therefore, it was confirmed from the results of this in vitro study that VB1 and VB3 may affect to Dex to promote MSCs in rat bone marrow cells for proliferation and differentiation into hard tissue-forming cells and the formation of calcified nodule aggregates.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"乙第1667号"}]},"item_10006_relation_14":{"attribute_name":"関連情報","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.11344/nano.15.51","subitem_relation_type_select":"DOI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"Nano Biomedicine. 2023, 15(2), p. 51-65."}]}]},"item_10006_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2023 Nano Biomedical Society","subitem_rights_language":"en"},{"subitem_rights":"Creative Commons Attribution-NoDerivs 4.0 International","subitem_rights_language":"en","subitem_rights_resource":"https://creativecommons.org/licenses/by-nd/4.0/"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"作成者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"仲間, ひとみ","creatorNameLang":"ja"},{"creatorName":"ナカマ, ヒトミ","creatorNameLang":"ja-Kana"},{"creatorName":"Nakama, Hitomi","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-06-27"}],"filename":"otu_1667_ab.pdf","filesize":[{"value":"293 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"論文内容要旨・審査結果要旨","objectType":"abstract","url":"https://osaka-dent.repo.nii.ac.jp/record/2000129/files/otu_1667_ab.pdf"},"version_id":"91621c05-8f51-49cd-a7a9-59ab25e72f5c"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-06-27"}],"filename":"otu_1667_fulltext.pdf","filesize":[{"value":"2.8 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"学位論文","objectType":"fulltext","url":"https://osaka-dent.repo.nii.ac.jp/record/2000129/files/otu_1667_fulltext.pdf"},"version_id":"d490ae93-9166-410f-aca0-7677837f5a97"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Vitamin B","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Calcified nodules","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Bone marrow cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Dexamethasone","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Effects of Vitamins Added to Culture Medium for Calcified Nodule Formation by Rat Bone Marrow Cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effects of Vitamins Added to Culture Medium for Calcified Nodule Formation by Rat Bone Marrow Cells","subitem_title_language":"en"},{"subitem_title":"ラット骨髄細胞培養における石灰化結節形成に対するビタミン添加の効果","subitem_title_language":"ja"}]},"item_type_id":"10006","owner":"18","path":["64"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-06-27"},"publish_date":"2024-06-27","publish_status":"0","recid":"2000129","relation_version_is_last":true,"title":["Effects of Vitamins Added to Culture Medium for Calcified Nodule Formation by Rat Bone Marrow Cells"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-08-27T06:25:32.916577+00:00"}