{"created":"2024-08-28T03:06:58.484671+00:00","id":2000130,"links":{},"metadata":{"_buckets":{"deposit":"2ea35f89-471f-476b-8d44-fef5723ffe33"},"_deposit":{"created_by":18,"id":"2000130","owner":"18","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"2000130"},"status":"published"},"_oai":{"id":"oai:osaka-dent.repo.nii.ac.jp:02000130","sets":["1686642104765:1:1724813534049:1724813728424"]},"author_link":[],"control_number":"2000130","item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2024-06-26"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"大阪歯科大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Osaka Dental University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"34408","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）","subitem_degreename_language":"ja"}]},"item_10006_description_7":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"We investigated the effect of synthesized collagen model polypeptides consisting of a proline-hydroxyproline-glycine (poly(PHG)) sequence combined with porous alpha-tricalcium phosphate (α-TCP) particles on bone formation in a mandibular canine defect model. The porous α-TCP particles were mixed with a poly(PHG) solution, and the obtained sponge was then cross-linked and analyzed by scanning electron microscopy. The optimal mixing concentration of α-TCP granules and the poly(PHG) solution was decided to be 0.15g/mL by compression testing.  The osteoblastic differentiation with the ALP activity of human mesenchymal stromal cells (hMSCs) cultured on the poly(PHG)/α-TCP was slightly greater than that of hMSCs cultured on the poly(PHG). Mandibular defects were analyzed in healthy beagles using micro-computed tomography and histological evaluation. At 2 and 4 weeks, the volume density of new bone was grater in the poly(PHG)/α-TCP group than in the group with only poly(PHG) (p < 0.05); however, there was no difference at 8 weeks (p > 0.05). Histological evaluation at 4 weeks after implantation revealed that the poly(PHG) had degraded and that newly formed bone was present on the surface of the α-TCP particles. This study demonstrates that the composite created using porous α-TCP particles and poly(PHG) is sufficiently adaptable for treating the mandibular defect model.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"乙第1668号"}]},"item_10006_relation_14":{"attribute_name":"関連情報","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.18905/jodu.57.2_223","subitem_relation_type_select":"DOI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"Journal of Osaka Dental University. 2023, 57(2), p. 223-231."}]}]},"item_10006_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2024 The Author(s)","subitem_rights_language":"en"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"作成者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"譚, 程","creatorNameLang":"ja"},{"creatorName":"タン, テイ","creatorNameLang":"ja-Kana"},{"creatorName":"Tan, Cheng","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-08-28"}],"filename":"otu_1668_ab.pdf","filesize":[{"value":"253 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"論文内容要旨・審査結果要旨","objectType":"abstract","url":"https://osaka-dent.repo.nii.ac.jp/record/2000130/files/otu_1668_ab.pdf"},"version_id":"533a46ee-216e-42c3-9f27-267d48e1c3ff"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-10-30"}],"filename":"otu_1668_fulltext.pdf","filesize":[{"value":"835 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"学位論文","objectType":"fulltext","url":"https://osaka-dent.repo.nii.ac.jp/record/2000130/files/otu_1668_fulltext.pdf"},"version_id":"e8fb212d-ac9c-49d4-b0ae-bf46fe0d2198"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Bone formation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"collagen model polypeptides","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"alpha- tricalcium phosphate","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Bone formation with a collagen model polypeptides/alpha- tricalcium phosphate sponge in a mandibular canine defect model","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Bone formation with a collagen model polypeptides/alpha- tricalcium phosphate sponge in a mandibular canine defect model","subitem_title_language":"en"},{"subitem_title":"下顎骨骨欠損モデルにおけるコラーゲンモデルポリペプチド/αリン酸三カルシウムスポンジによる骨形成","subitem_title_language":"ja"}]},"item_type_id":"10006","owner":"18","path":["1724813728424"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-08-28"},"publish_date":"2024-08-28","publish_status":"0","recid":"2000130","relation_version_is_last":true,"title":["Bone formation with a collagen model polypeptides/alpha- tricalcium phosphate sponge in a mandibular canine defect model"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-10-30T02:39:07.886611+00:00"}