{"created":"2025-04-30T05:06:59.031644+00:00","id":2000174,"links":{},"metadata":{"_buckets":{"deposit":"e30f98ce-f677-4318-9a44-8ca15274dd90"},"_deposit":{"created_by":18,"id":"2000174","owner":"18","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"2000174"},"status":"published"},"_oai":{"id":"oai:osaka-dent.repo.nii.ac.jp:02000174","sets":["1686642104765:1:1724813534049:1724813725424"]},"author_link":[],"control_number":"2000174","item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2025-03-07"}]},"item_10006_degree_grantor_9":{"attribute_name":"item_10006_degree_grantor_9","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"大阪歯科大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Osaka Dental University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"34408","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）","subitem_degreename_language":"ja"}]},"item_10006_description_7":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Dental desensitizing materials are often applied to wedge defects, potentially allowing the material to come into contact with pulp cells. In this study, we aimed to clarify cell proliferation, calcium dynamics, and expression of integrin αvβ3 by culturing cells in a medium containing a calcium carbonate-based dental hypersensitivity treatment agent.\nIn this experiment, we performed a WST assay and observed fluorescently la- beled antibodies using a confocal laser scanning microscope. The number of cells increased in the experimental group compared to the control group on day 1 of incu- bation. On days 4 and 7 of incubation, material-derived calcium was localized in the cytoplasm of the experimental group, overlapping with the Integrin αvβ3 expression sites. It was suggested that calcium derived from the material is taken up into the cytoplasm and promotes cell proliferation in the early stages of culture.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"dissertation_number","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第1016号"}]},"item_10006_relation_14":{"attribute_name":"関連情報","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"en","subitem_relation_name_text":"Journal of Oral Tissue Engineering,2024,22(1),20-28"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.jstage.jst.go.jp/article/jarde/22/1/22_jarde22_23/_article/-char/ja","subitem_relation_type_select":"DOI"}}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"作成者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"磯野, 治実","creatorNameLang":"ja"},{"creatorName":"イソノ, ハルミ","creatorNameLang":"ja-Kana"},{"creatorName":"Harumi, Isono","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2025-04-30"}],"filename":"kou_1016_ab.pdf","filesize":[{"value":"249 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"論文内容要旨・審査結果要旨","objectType":"abstract","url":"https://osaka-dent.repo.nii.ac.jp/record/2000174/files/kou_1016_ab.pdf"},"version_id":"1f0f8160-103b-4049-a086-600ec8fde80d"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"calcium","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cell proliferation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"dentin hypersensitivity","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"human deciduous dental pulp fibroblast like cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"integrin","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Effect of a Novel Calcium Carbonate-based Hypersensitivity Suppression Material on Integrin αvβ3 Expression in Human Deciduous Dental Pulp-deribed Fibroblasts","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effect of a Novel Calcium Carbonate-based Hypersensitivity Suppression Material on Integrin αvβ3 Expression in Human Deciduous Dental Pulp-deribed Fibroblasts","subitem_title_language":"en"},{"subitem_title":"炭酸カルシウム系新規知覚過敏抑制材料がヒト乳歯歯髄由来線維芽細胞のIntegrin αvβ3発現に与える影響","subitem_title_language":"ja"}]},"item_type_id":"10006","owner":"18","path":["1724813725424"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2025-04-30"},"publish_date":"2025-04-30","publish_status":"0","recid":"2000174","relation_version_is_last":true,"title":["Effect of a Novel Calcium Carbonate-based Hypersensitivity Suppression Material on Integrin αvβ3 Expression in Human Deciduous Dental Pulp-deribed Fibroblasts"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2025-04-30T06:12:52.284506+00:00"}