{"created":"2023-05-15T13:57:29.943172+00:00","id":206,"links":{},"metadata":{"_buckets":{"deposit":"6643edd7-4aaa-426b-aee7-1f1e2270dce4"},"_deposit":{"created_by":16,"id":"206","owners":[16],"pid":{"revision_id":0,"type":"depid","value":"206"},"status":"published"},"_oai":{"id":"oai:osaka-dent.repo.nii.ac.jp:00000206","sets":["1686642104765:1:35:39"]},"author_link":["588","587"],"item_10006_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"異なる組成のエピガロカテキンガレート結合ゼラチンは再生骨の骨質を変化させる"}]},"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2019-03-08"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"大阪歯科大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"34408","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）"}]},"item_10006_description_10":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_description":"2018年度","subitem_description_type":"Other"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Bone quality is a significant indicator of the result of bone treatments. However, information regarding the quality of regenerated bones is limited. The study investigates the effect of different compositions of vacuum heated epigallocatechin gallate-modified gelatins sponge (vhEGCG-GS) on the quality of regenerated bones in critical size defects (9 mm) of rat calvariae. Five different compositions of vhEGCG-GSs containing the same amount of EGCG and different amounts of gelatin were tested. Following four weeks after implantation, the harvested regenerated bones were evaluated by using micro-computed tomography analysis, histological evaluation (hematoxylin-eosin and Villaneueva Goldner staining), picrosirius red-staining with polarized microscopic observation for collagen maturation, and Fourier transform infrared spectroscopy microscopy and imaging analysis for mineral-matrix ratio. The results indicated that increasing content of gelatin in the vhEGCG-GSs promoted bone and osteoid formation but yielded porous bones. Furthermore, tissue mineral density decreased and the maximum mineral-matrix ratio increased. In contrast, vhEGCG-GSs containing smaller amount of gelatin formed mature collagen matrix in the regenerated bones. These results suggest that the alteration of composition of vhEGCG-GSs affected the bone forming capability and quality of regenerated bone and provides valuable insight for the fabrication of new bone substitute materials.","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第834号"}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"原, 瑛紀"},{"creatorName":"ハラ, エイキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"587","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hara, Eiki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"588","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-08"}],"displaytype":"detail","filename":"kou_834_txt.pdf","filesize":[{"value":"6.1 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"学位論文","url":"https://osaka-dent.repo.nii.ac.jp/record/206/files/kou_834_txt.pdf"},"version_id":"ceb620f9-6840-4241-a872-fb69537e821b"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-05-17"}],"displaytype":"detail","filename":"kou_834.pdf","filesize":[{"value":"226.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"論文内容要旨・審査結果要旨","url":"https://osaka-dent.repo.nii.ac.jp/record/206/files/kou_834.pdf"},"version_id":"557793ea-82dd-4c00-911e-38ca48378738"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"bone quality","subitem_subject_scheme":"Other"},{"subitem_subject":"EGCG","subitem_subject_scheme":"Other"},{"subitem_subject":"bone formation","subitem_subject_scheme":"Other"},{"subitem_subject":"gelatin","subitem_subject_scheme":"Other"},{"subitem_subject":"collagen","subitem_subject_scheme":"Other"},{"subitem_subject":"FTIR imaging","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Epigallocatechin Gallate-Modified Gelatins with Different Compositions Alter the Quality of Regenerated Bones","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Epigallocatechin Gallate-Modified Gelatins with Different Compositions Alter the Quality of Regenerated Bones"}]},"item_type_id":"10006","owner":"16","path":["39"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-05-17"},"publish_date":"2019-05-17","publish_status":"0","recid":"206","relation_version_is_last":true,"title":["Epigallocatechin Gallate-Modified Gelatins with Different Compositions Alter the Quality of Regenerated Bones"],"weko_creator_id":"16","weko_shared_id":-1},"updated":"2023-05-15T15:23:14.375309+00:00"}