{"created":"2023-05-15T13:57:30.664309+00:00","id":217,"links":{},"metadata":{"_buckets":{"deposit":"f314e94e-fab4-407a-863d-149630e46591"},"_deposit":{"created_by":16,"id":"217","owners":[16],"pid":{"revision_id":0,"type":"depid","value":"217"},"status":"published"},"_oai":{"id":"oai:osaka-dent.repo.nii.ac.jp:00000217","sets":["1686642104765:1:35:39"]},"author_link":["608","607"],"item_10006_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"エナメル上皮腫におけるE-, P-, N-cadherin, α-, β-, γ-cateninの発現の検討"}]},"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2019-03-08"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"大阪歯科大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"34408","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）"}]},"item_10006_description_10":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_description":"2018年度","subitem_description_type":"Other"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Ameloblastoma consists of an odontogenic epithelium and is a benign tumor without odontogenic mesenchyme. It occurs primarily in the jawbone and exhibits locally invasive growth. \nTo clarify the factors involved in the invasion of ameloblastoma, the expression profiles of E-, P- and N-cadherin and α-, β- and γ-catenin were examined in 39 cases of ameloblastoma by immunohistochemistry. \nCadherin and catenin were expressed on tumor cell membranes. Of the examined cases, 12 exhibited reduced E-cadherin expression, 12 exhibited strong P-cadherin expression, and 7 exhibited weak expression of N-cadherin. Additionally, 20 cases exhibited reduced α-catenin expression, 8 exhibited reduced β-catenin expression, and 33 cases exhibited reduced γ-catenin expression. \nReduced expression of E-cadherin was associated with decreased cell adhesion, and strong expression of P-cadherin was associated with cell proliferation. Expression of N-cadherin was related to tumor invasion and suggested involvement in epithelial mesenchymal transition. In addition, reduced α-catenin in the expression region of E-cadherin suggested an abnormal function of E-cadherin. \nTogether, these results suggest that cadherin and catenin play important roles in the development and local invasiveness of ameloblastoma.\n","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第845号"}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"成瀬, かおり"},{"creatorName":"ナルセ, カオリ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"607","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Naruse, Kaori","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"608","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-09"}],"displaytype":"detail","filename":"kou_845_txt.pdf","filesize":[{"value":"2.2 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"学位論文","url":"https://osaka-dent.repo.nii.ac.jp/record/217/files/kou_845_txt.pdf"},"version_id":"8378df06-b8c2-47f5-9ba0-5daf261ab9e6"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-05-17"}],"displaytype":"detail","filename":"kou_845.pdf","filesize":[{"value":"248.7 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"論文内容要旨・審査結果要旨","url":"https://osaka-dent.repo.nii.ac.jp/record/217/files/kou_845.pdf"},"version_id":"64a5d511-6e80-455c-a800-0fd429d16cc4"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"cadherin","subitem_subject_scheme":"Other"},{"subitem_subject":"catenin","subitem_subject_scheme":"Other"},{"subitem_subject":"ameloblastoma","subitem_subject_scheme":"Other"},{"subitem_subject":"immunohistochemistry","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Expression of E-, P-, and N-cadherin and α-, β-, and γ-catenin with respect to invasion in ameloblastoma","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Expression of E-, P-, and N-cadherin and α-, β-, and γ-catenin with respect to invasion in ameloblastoma"}]},"item_type_id":"10006","owner":"16","path":["39"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-05-17"},"publish_date":"2019-05-17","publish_status":"0","recid":"217","relation_version_is_last":true,"title":["Expression of E-, P-, and N-cadherin and α-, β-, and γ-catenin with respect to invasion in ameloblastoma"],"weko_creator_id":"16","weko_shared_id":-1},"updated":"2023-05-15T15:22:12.547536+00:00"}