{"created":"2023-05-15T13:57:32.089895+00:00","id":243,"links":{},"metadata":{"_buckets":{"deposit":"c75350ea-164c-4326-823c-206b5fe462e4"},"_deposit":{"created_by":16,"id":"243","owners":[16],"pid":{"revision_id":0,"type":"depid","value":"243"},"status":"published"},"_oai":{"id":"oai:osaka-dent.repo.nii.ac.jp:00000243","sets":["1686642104765:1:40:44"]},"author_link":["659","658"],"item_10006_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"ERK1/2 シグナル伝達経路を介したヒト歯肉線維芽細胞におけるShikonin の生物学的効果"}]},"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2020-03-06"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"大阪歯科大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"34408","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）"}]},"item_10006_description_10":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_description":"2019年度","subitem_description_type":"Other"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Shikonin is an active ingredient in Lithospermum erythrorhizon that　promotes wound healing. We examined wound healing by shikonin using human　gingival fibroblasts (hGF) collected from patients. We determined the optimal　concentration from the result of cell proliferation and migration. And then we　investigated the expression of VEGF, FN and Type I collagen. Moreover, we examined　the phosphorylation of ERK 1/2 involved in wound healing. Finally, we performed all experiments using ERK 1/2 specific inhibitor (PD98059).Shikonin 1μM significantly promote cell proliferation and migration, shikonin promoted the expression of VEGF, FN and Type I collagen. Also, shikonin enhanced the activation of ERK 1/2 phosphorylation PD98059 suppressed the these effects of shikonin. In conclusion, wefound that shikonin might be useful in gingival wound healing.","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第860号"}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"今井, 一貴"},{"creatorName":"イマイ, カズタカ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"658","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Imai, Kazutaka","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"659","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-09-18"}],"displaytype":"detail","filename":"kou_860_txt.pdf","filesize":[{"value":"5.8 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"学位論文","url":"https://osaka-dent.repo.nii.ac.jp/record/243/files/kou_860_txt.pdf"},"version_id":"a335bab1-80e9-4ace-a0b8-3711f5898da4"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-04-28"}],"displaytype":"detail","filename":"kou_860.pdf","filesize":[{"value":"211.5 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"論文内容要旨・審査結果要旨","url":"https://osaka-dent.repo.nii.ac.jp/record/243/files/kou_860.pdf"},"version_id":"2e3e51ff-f03b-4015-92df-fdc98f191699"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Shikonin ｜Wound healing ｜Gingival Fibroblasts","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Biological Effects of Shikonin in Human Gingival Fibroblasts via ERK 1/2 Signaling Pathway","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Biological Effects of Shikonin in Human Gingival Fibroblasts via ERK 1/2 Signaling Pathway"}]},"item_type_id":"10006","owner":"16","path":["44"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-04-28"},"publish_date":"2020-04-28","publish_status":"0","recid":"243","relation_version_is_last":true,"title":["Biological Effects of Shikonin in Human Gingival Fibroblasts via ERK 1/2 Signaling Pathway"],"weko_creator_id":"16","weko_shared_id":-1},"updated":"2023-05-15T15:26:40.422532+00:00"}