{"created":"2023-05-15T13:57:33.053102+00:00","id":260,"links":{},"metadata":{"_buckets":{"deposit":"2a80800e-92bb-497d-8239-c1df83fb68d4"},"_deposit":{"created_by":16,"id":"260","owners":[16],"pid":{"revision_id":0,"type":"depid","value":"260"},"status":"published"},"_oai":{"id":"oai:osaka-dent.repo.nii.ac.jp:00000260","sets":["1686642104765:1:40:44"]},"author_link":["688","705"],"item_10006_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"ヒト骨髄間葉系細胞の硬組織分化における Porphyromonas gingivalis LPS存在下での高グルコース環境の影響"}]},"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2020-03-06"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"大阪歯科大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"34408","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）"}]},"item_10006_description_10":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_description":"2019年度","subitem_description_type":"Other"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Chronic inflammation contributes to the development of DM and DM-associated complications. Hyperglycemia is a hallmark of DM and may contribute to sustained inflammation by increasing the levels of proinflammatory cytokines. However, the mechanisms by which bone-related complications develop in DM after stimulation by the Porphyromonas gingivalis lipopolysaccharide (P. gingivalis LPS) remain unknown.  We evaluated the effect of high glucose levels on the biomineralization and inflammation markers in a human osteoblastic cell line, after stimulation with LPS from P. gingivalis. We treated cells with glucose at concentrations 5.5, 8.0, 12 and 24 mM after stimulation with P. gingivalis LPS (1.0 mg/ml) and determined its effects on cell proliferation, alkaline phosphatase (ALP) activity, osteocalcin (OCN) production, calcium deposition, inflammatory cytokines, and osteogenic cytokines. . High glucose concentration decreased hard tissue formation after stimulation by P. gingivalis LPS. Understanding the effect of glucose on osteoblast differentiation and Ca deposition might provide a better understanding of the development and prevention of periodontitis associated with diabetes.","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第877号"}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"塩見, 慧"},{"creatorName":"シオミ, ケイ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"688","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shiomi, Kei","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"705","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-09-18"}],"displaytype":"detail","filename":"kou_877_txt.pdf","filesize":[{"value":"3.2 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"学位論文","url":"https://osaka-dent.repo.nii.ac.jp/record/260/files/kou_877_txt.pdf"},"version_id":"b29d09f0-c29f-4e3d-9f72-8b743602b3a6"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-04-28"}],"displaytype":"detail","filename":"kou_877.pdf","filesize":[{"value":"292.0 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"論文内容要旨・審査結果要旨","url":"https://osaka-dent.repo.nii.ac.jp/record/260/files/kou_877.pdf"},"version_id":"2a88ba74-d084-47c0-86f1-6540080204db"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Bone marrow cells","subitem_subject_scheme":"Other"},{"subitem_subject":"Hyperglycemia","subitem_subject_scheme":"Other"},{"subitem_subject":"Porphyromonas gingivalis","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Osteogenic Effects of Glucose Concentration for Human Bone Marrow Stromal Cells after Stimulation with Porphyromonas gingivalis Lipopolysaccharide.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Osteogenic Effects of Glucose Concentration for Human Bone Marrow Stromal Cells after Stimulation with Porphyromonas gingivalis Lipopolysaccharide."}]},"item_type_id":"10006","owner":"16","path":["44"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-04-28"},"publish_date":"2020-04-28","publish_status":"0","recid":"260","relation_version_is_last":true,"title":["Osteogenic Effects of Glucose Concentration for Human Bone Marrow Stromal Cells after Stimulation with Porphyromonas gingivalis Lipopolysaccharide."],"weko_creator_id":"16","weko_shared_id":-1},"updated":"2023-05-15T15:24:56.914130+00:00"}