{"created":"2023-05-15T13:57:36.232188+00:00","id":314,"links":{},"metadata":{"_buckets":{"deposit":"a6dabcdd-c369-440b-a8ca-695548db2664"},"_deposit":{"created_by":16,"id":"314","owners":[16],"pid":{"revision_id":0,"type":"depid","value":"314"},"status":"published"},"_oai":{"id":"oai:osaka-dent.repo.nii.ac.jp:00000314","sets":["1686642104765:1:53:56"]},"author_link":["799","798"],"item_10006_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"UV/オゾン処理した純チタン金属の免疫調節機能が抗菌性及び骨形成に与える影響"}]},"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2022-03-04"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"大阪歯科大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"34408","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）"}]},"item_10006_description_10":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_description":"2021年度","subitem_description_type":"Other"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The immunomodulatory antibacterial activity and osteoimmunomodulatory properties of implantable bio- materials significantly influence bone regeneration. Various types of ultraviolet (UV) instrument are currently in use to greatly enhance the antibacterial activity and osteoconductive capability of titanium, it remains unclear how UV treatment modulates immune response. Compared to traditional UV treatment, the combination of low- dose ozone with UV irradiation is considered a new option to give benefits to surface modification and reduce the drawbacks of UV and ozone individually. Herein, the aim of this study was to elucidate the immune-modulatory properties of macrophages on UV/ozone-irradiated titanium that serve as defense against S. aureus and the crosstalk between immune cells and osteoblasts. Three different cell and bacteria co-culture systems were developed in order to investigate the race between host cells and bacteria to occupy the surface. In vitro immunological experiments indicated that UV/ozone irradiation significantly enhanced the phagocytic and bactericidal activity of macrophages against S. aureus. Further, in vitro and in vivo studies evidenced the favorable osteoimmune environment for osteogenic differentiation and bone formation. This research suggests vital therapeutic potential of UV/ozone irradiation for preventing the biomaterial-associated infections and achieving favorable bone formation simultaneously.","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第917号"}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"楊, 元元 "},{"creatorName":"ヨウ, ゲンゲン","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"798","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yang, Yuanyuan","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"799","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-05-13"}],"displaytype":"detail","filename":"kou_917_txt.pdf","filesize":[{"value":"1.6 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"学位論文","url":"https://osaka-dent.repo.nii.ac.jp/record/314/files/kou_917_txt.pdf"},"version_id":"4bd50ccb-63a8-4829-8b05-f3ab527ccb0a"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-05-13"}],"displaytype":"detail","filename":"kou_917.pdf","filesize":[{"value":"252.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"論文内容要旨・審査結果要旨","url":"https://osaka-dent.repo.nii.ac.jp/record/314/files/kou_917.pdf"},"version_id":"6fe3a96c-859f-464d-a383-b143b5f38db4"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Immune response｜UV/ozone irradiation｜Immunomodulatory ｜antibacterial ｜Osteoimmunomodulation","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"UV/ozone irradiation manipulates immune response for antibacterial activity and bone regeneration on titanium","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"UV/ozone irradiation manipulates immune response for antibacterial activity and bone regeneration on titanium"}]},"item_type_id":"10006","owner":"16","path":["56"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-05-13"},"publish_date":"2022-05-13","publish_status":"0","recid":"314","relation_version_is_last":true,"title":["UV/ozone irradiation manipulates immune response for antibacterial activity and bone regeneration on titanium"],"weko_creator_id":"16","weko_shared_id":-1},"updated":"2023-05-15T14:06:40.481313+00:00"}