{"created":"2023-05-15T13:57:37.595464+00:00","id":336,"links":{},"metadata":{"_buckets":{"deposit":"4c0c35d7-634f-413c-affc-a649cbb6bc6e"},"_deposit":{"created_by":16,"id":"336","owners":[16],"pid":{"revision_id":0,"type":"depid","value":"336"},"status":"published"},"_oai":{"id":"oai:osaka-dent.repo.nii.ac.jp:00000336","sets":["1686642104765:1:53:56"]},"author_link":["841","840"],"item_10006_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"ラット頭蓋冠欠損モデルにおける-リン酸三カルシウムとゼラチンの複合スポンジを用いた脱分化脂肪細胞による骨再生"}]},"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2022-03-04"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"大阪歯科大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"34408","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）"}]},"item_10006_description_10":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_description":"2021年度","subitem_description_type":"Other"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Mechanical and resorbable scaffolds are in high demand for stem cell-based regenerative medi-cine, to treat refractory bone defects in craniofacial abnormalities and injuries. Multipotent pro-genitor cells, such as dedifferentiated fat (DFAT) cells, are prospective sources for regenerative therapies. Herein, we aimed to demonstrate that a composite gelatin sponge (α-TCP/GS) of al-fa-tricalcium phosphate (α-TCP) mixed with gelatin scaffolds (GS), with/without DFATs, induced bone regeneration in a rat calvarial defect model in vivo. α-TCP/GS was prepared by mixing α-TCP and 2% GS using vacuum-heated methods. α-TCP/GS samples with/without DFATs were transplanted into the model. After 4 weeks of implantation, the samples were subjected to mi-cro-computed tomography (μ-CT) and histological analysis. α-TCP/GS possessed adequate me-chanical strength; α-TCP did not convert to hydroxyapatite upon contact with water, as deter-mined by X-ray diffraction. Moreover, stable α-TCP/GS was formed by electrostatic interactions, and verified based on the infrared peak shifts. μ-CT analyses showed that bone formation was higher in the α-TCP/GS+ DFAT group than in the α-TCP/GS group. Therefore, the implantation of α-TCP/GS comprising DFAT cells enhanced bone regeneration and vascularization, demon-strating the potential for healing critical-sized bone defects.","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第938号"}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"妻野, 誠仁"},{"creatorName":"ツマノ, ノブヒト","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"840","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nsumano, Nobuhito","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"841","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-05-13"}],"displaytype":"detail","filename":"kou_938_txt.pdf","filesize":[{"value":"1.9 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"学位論文","url":"https://osaka-dent.repo.nii.ac.jp/record/336/files/kou_938_txt.pdf"},"version_id":"243f8449-a6df-489f-af2e-63fb1cd559c3"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-05-13"}],"displaytype":"detail","filename":"kou_938.pdf","filesize":[{"value":"240.8 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"論文内容要旨・審査結果要旨","url":"https://osaka-dent.repo.nii.ac.jp/record/336/files/kou_938.pdf"},"version_id":"f81ee2b2-d842-43d0-8b7d-968af5797747"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"bone regeneration","subitem_subject_scheme":"Other"},{"subitem_subject":"alfa-tricalcium phosphate","subitem_subject_scheme":"Other"},{"subitem_subject":"animal study","subitem_subject_scheme":"Other"},{"subitem_subject":"dedifferentiated fat cells","subitem_subject_scheme":"Other"},{"subitem_subject":"rat calvar-ial defect","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Bone Regeneration by Dedifferentiated Fat Cells Using Composite Sponge of Alfa-Tricalcium Phosphate and Gelatin in a Rat Calvarial Defect Model","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Bone Regeneration by Dedifferentiated Fat Cells Using Composite Sponge of Alfa-Tricalcium Phosphate and Gelatin in a Rat Calvarial Defect Model"}]},"item_type_id":"10006","owner":"16","path":["56"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-05-13"},"publish_date":"2022-05-13","publish_status":"0","recid":"336","relation_version_is_last":true,"title":["Bone Regeneration by Dedifferentiated Fat Cells Using Composite Sponge of Alfa-Tricalcium Phosphate and Gelatin in a Rat Calvarial Defect Model"],"weko_creator_id":"16","weko_shared_id":-1},"updated":"2023-05-15T14:05:36.850862+00:00"}