{"created":"2023-05-15T13:57:21.806279+00:00","id":34,"links":{},"metadata":{"_buckets":{"deposit":"a99069be-4736-4dc7-9702-25f01a14f2fe"},"_deposit":{"created_by":14,"id":"34","owners":[14],"pid":{"revision_id":0,"type":"depid","value":"34"},"status":"published"},"_oai":{"id":"oai:osaka-dent.repo.nii.ac.jp:00000034","sets":["1686642104765:1:6:8"]},"author_link":["382","101"],"item_10006_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"下⻭槽神経損傷による孤束核内のマイクログリアの活性化"}]},"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2015-03-06"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"大阪歯科大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"34408","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）"}]},"item_10006_description_10":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_description":"2014年度","subitem_description_type":"Other"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Deafferentation of somatosensory trigeminal nerves innervating dental pulp and periodontal tissue results in a higher taste threshold persisting for a long time in humans. The dental and taste nerves converge on neurons in the rostral nucleus of the solitary tract (rNST), suggesting somatosensory and taste input interact in processing taste information in the rNST. Peripheral injury to the inferior alveolar nerve (IAN), one of the dental nerves, leads to glial responses predominantly in the trigeminal spinal subnucleus caudalis and spinal dorsal horn, and abnormal pain sensation via a mechanism involving the active microglia. We examined the microglial response in another primary IAN terminal, the NST, after transection of the IAN (IANx) to reveal a mechanism of abnormal taste sensation after peripheral injury to the dental nerves. By 7 days post-IANx, a cluster of microglial cells appeared in and around the rostral-most portion of the NST, indicating that nerve damage to the IAN results in a microglial response in the rNST, which may participate in initiating abnormal taste sensations following IAN injury.","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第746号"}]},"item_10006_publisher_5":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"大阪歯科学会"}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"柿原, 理奈"},{"creatorName":"カキハラ, リナ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kakihara, Rina","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-08-01"}],"displaytype":"detail","filename":"kou_746_txt..pdf","filesize":[{"value":"430.2 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"学位論文","url":"https://osaka-dent.repo.nii.ac.jp/record/34/files/kou_746_txt..pdf"},"version_id":"7c1c9c0e-c102-4222-a6d2-b87fc5356a04"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-08-01"}],"displaytype":"detail","filename":"kou_746.pdf","filesize":[{"value":"175.8 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"論文内容要旨・審査結果要旨","url":"https://osaka-dent.repo.nii.ac.jp/record/34/files/kou_746.pdf"},"version_id":"e16a1267-9fc8-43bb-aab9-ea5d5e7555ee"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Microglia","subitem_subject_scheme":"Other"},{"subitem_subject":"Nucleus of solitary tract (NST)","subitem_subject_scheme":"Other"},{"subitem_subject":"Inferior alveolar nerve (IAN)","subitem_subject_scheme":"Other"},{"subitem_subject":"Microglia","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Nucleus of solitary tract (NST)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Inferior alveolar nerve (IAN)","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Activation of microglia in the nucleus of the solitary tract by inferior alveolar nerve injury","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Activation of microglia in the nucleus of the solitary tract by inferior alveolar nerve injury"}]},"item_type_id":"10006","owner":"14","path":["8"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-08-01"},"publish_date":"2016-08-01","publish_status":"0","recid":"34","relation_version_is_last":true,"title":["Activation of microglia in the nucleus of the solitary tract by inferior alveolar nerve injury"],"weko_creator_id":"14","weko_shared_id":14},"updated":"2023-05-15T14:12:06.430149+00:00"}