{"created":"2023-05-15T13:57:38.568712+00:00","id":351,"links":{},"metadata":{"_buckets":{"deposit":"76123ea7-ed4d-4375-8452-2653809c2839"},"_deposit":{"created_by":16,"id":"351","owners":[16],"pid":{"revision_id":0,"type":"depid","value":"351"},"status":"published"},"_oai":{"id":"oai:osaka-dent.repo.nii.ac.jp:00000351","sets":["1686642104765:1:57:60"]},"author_link":["870"],"control_number":"351","item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2023-03-03"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"大阪歯科大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Osaka Dental University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"34408","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）","subitem_degreename_language":"ja"}]},"item_10006_description_7":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"The present study investigated the effects of a co-stimulation with surface reaction-type pre-reacted glass-ionomer (S-PRG) filler eluate and muramyl dipeptide (MDP) on matrix metalloproteinase (MMP)-1 production by human dental pulp fibroblast-like cells (hDPFs). S-PRG filler eluate contains 6 ions (F, Na, Al, B, Sr, and Si) released from S-PRG filler. Each S-PRG filler eluate and MDP stimulation enhanced MMP-1 production by hDPFs. The co-stimulation with S-PRG filler eluate and MDP enhanced MMP-1 production more than the MDP stimulation alone. A similar stimulation induced the phosphorylation of ERK 1/2. The increased secretion of MMP-1 and enhanced phosphorylation of ERK 1/2 by the co-stimulation with S-PRG filler eluate and MDP were suppressed by the selective and potent CaSR antagonist NPS 2143. Since strontium binds to CaSR, these results suggest that the enhanced production of MMP-1 by the co-stimulation with S-PRG filler eluate and MDP was due to the effects of strontium.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第943号"}]},"item_10006_relation_14":{"attribute_name":"関連情報","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.4012/dmj.2022-201","subitem_relation_type_select":"DOI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"Dental Materials Journal. 2023, 42(3), p. 375-382."}]}]},"item_10006_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2023 The Japanese Society for Dental Materials and Devices","subitem_rights_language":"en"}]},"item_1696310207136":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"作成者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"諸頭, 秀俊","creatorNameLang":"ja"},{"creatorName":"モロトウ, ヒデトシ","creatorNameLang":"ja-Kana"},{"creatorName":"Moroto, Hidetoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"870","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-04-04"}],"filename":"kou_943.pdf","filesize":[{"value":"254.7 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"論文内容要旨・審査結果要旨","objectType":"abstract","url":"https://osaka-dent.repo.nii.ac.jp/record/351/files/kou_943.pdf"},"version_id":"3046a771-b10f-4c03-bf71-a17f475a4dbd"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-03-01"}],"filename":"kou_943_fulltxt.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"学位論文","objectType":"fulltext","url":"https://osaka-dent.repo.nii.ac.jp/record/351/files/kou_943_fulltxt.pdf"},"version_id":"de2c72a9-7eef-4af2-a50f-20df29ee39e7"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"S-PRG filler eluate","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Muramyl dipeptide","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Effects of a co-stimulation with S-PRG filler eluate and muramyl dipeptide (MDP) on matrix metalloproteinase-1 production by human dental pulp fibroblast-like cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effects of a co-stimulation with S-PRG filler eluate and muramyl dipeptide (MDP) on matrix metalloproteinase-1 production by human dental pulp fibroblast-like cells","subitem_title_language":"en"},{"subitem_title":"ヒト歯髄由来線維芽細胞様細胞におけるマトリックスメタロプロテアーゼ‐1産生に対するS-PRGフィラー溶出液およびムラミルジペプチド（MDP）による共刺激の影響","subitem_title_language":"ja"}]},"item_type_id":"10006","owner":"16","path":["60"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-04-04"},"publish_date":"2023-04-04","publish_status":"0","recid":"351","relation_version_is_last":true,"title":["Effects of a co-stimulation with S-PRG filler eluate and muramyl dipeptide (MDP) on matrix metalloproteinase-1 production by human dental pulp fibroblast-like cells"],"weko_creator_id":"16","weko_shared_id":-1},"updated":"2024-03-13T03:54:54.337229+00:00"}