{"created":"2023-05-15T13:57:38.614525+00:00","id":352,"links":{},"metadata":{"_buckets":{"deposit":"20fecb98-83cc-4265-a12b-9d3de704a36a"},"_deposit":{"created_by":16,"id":"352","owners":[16],"pid":{"revision_id":0,"type":"depid","value":"352"},"status":"published"},"_oai":{"id":"oai:osaka-dent.repo.nii.ac.jp:00000352","sets":["1686642104765:1:57:60"]},"author_link":["872"],"control_number":"352","item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2023-03-03"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"大阪歯科大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Osaka Dental University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"34408","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）","subitem_degreename_language":"ja"}]},"item_10006_description_7":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Reparative dentin formed by dental cavity preparation (DCP) is frequently used in clinical operations and plays a pivotal role in pulp protection. Recent reports have shown that senescent cells induced by various stressors aggravate many diseases. They can be treated using senolytics, which are drugs that selectively eliminate senescent cells. However, the association between DCP, senescent cells, and senolytics remains unclear. In this study, we established a rat model of DCP and analyzed the spatiotemporal localization of senescent cells in the pulp. The results showed that p21- and p16-positive senescent cells appeared mostly around the pulp horn (PH) under DCP. Furthermore, administration of senolytics (dasatinib and quercetin) successfully eliminated these senescent cells, thereby restoring the volume of reparative dentin formation. These data indicate that senescent cells induced by DCP may hamper the formation of reparative dentin. Senescent cells may be targets for the development of new restorative dentistry therapies.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第944号"}]},"item_10006_relation_14":{"attribute_name":"関連情報","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.4012/dmj.2022-245","subitem_relation_type_select":"DOI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"Dental Materials Journal. 2023, 42(3), p. 360-367."}]}]},"item_10006_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2023 The Japanese Society for Dental Materials and Devices","subitem_rights_language":"en"}]},"item_1696310207136":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"作成者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"劉, 海濤","creatorNameLang":"ja"},{"creatorName":"リュウ, ハイタオ","creatorNameLang":"ja-Kana"},{"creatorName":"Liu, Haitao","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"872","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-04-04"}],"filename":"kou_944.pdf","filesize":[{"value":"241.8 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"論文内容要旨・審査結果要旨","objectType":"abstract","url":"https://osaka-dent.repo.nii.ac.jp/record/352/files/kou_944.pdf"},"version_id":"550659e5-b05c-42dd-86c8-4bf1bc49c246"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-03-01"}],"filename":"kou_944_fulltxt.pdf","filesize":[{"value":"5.2 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"学位論文","objectType":"fulltext","url":"https://osaka-dent.repo.nii.ac.jp/record/352/files/kou_944_fulltxt.pdf"},"version_id":"a551084a-edab-4938-bb24-1432804706e5"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Senescence","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"senolytics","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cavity preparation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"reparative dentin","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Localization of senescent cells under cavity preparations in rats and restoration of reparative dentin formation by senolytics","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Localization of senescent cells under cavity preparations in rats and restoration of reparative dentin formation by senolytics","subitem_title_language":"en"},{"subitem_title":"ラット窩洞形成下における老化細胞の局在と老化細胞除去薬による修復象牙質形成の回復","subitem_title_language":"ja"}]},"item_type_id":"10006","owner":"16","path":["60"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-04-04"},"publish_date":"2023-04-04","publish_status":"0","recid":"352","relation_version_is_last":true,"title":["Localization of senescent cells under cavity preparations in rats and restoration of reparative dentin formation by senolytics"],"weko_creator_id":"16","weko_shared_id":-1},"updated":"2024-03-13T03:54:53.999044+00:00"}