{"created":"2023-05-15T13:57:38.896733+00:00","id":358,"links":{},"metadata":{"_buckets":{"deposit":"5dfbb6c8-73b2-4db3-ad8b-8ddcbb2bc547"},"_deposit":{"created_by":16,"id":"358","owners":[16],"pid":{"revision_id":0,"type":"depid","value":"358"},"status":"published"},"_oai":{"id":"oai:osaka-dent.repo.nii.ac.jp:00000358","sets":["1686642104765:1:57:60"]},"author_link":["884"],"control_number":"358","item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2023-03-03"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"大阪歯科大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Osaka Dental University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"34408","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）","subitem_degreename_language":"ja"}]},"item_10006_description_7":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"We investigated senescence in rat-derived dedifferentiated fat cells (rDFATs) with high passage numbers and analyzed the types of senescence-associated secretory phenotypes (SASPs) secreted from the rDFATs with replicative senescence. Senescent rDFATs showed a giant and flattened morphology and a low proliferative ability compared with non-senescent rDFATs. Moreover, 16 SASP-related genes (Ccl11, Ccl12, Ccl21, Ccl5, Csf2, Cxcl1, Cxcl12, Ifna2, IL11, IL12a, IL13, IL1a, IL1rn, IL6, Mif, Tnf) were significantly upregulated in the rDFATs with replicative senescence. These results indicate that DFATs also undergo cellular senescence during continuous passage cultures and may secrete various types of SASPs.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第950号"}]},"item_10006_relation_14":{"attribute_name":"関連情報","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.4012/dmj.2022-242","subitem_relation_type_select":"DOI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"Dental Materials Journal. 2023, 42(3), p. 351-359."}]}]},"item_10006_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2023 The Japanese Society for Dental Materials and Devices","subitem_rights_language":"en"}]},"item_1696310207136":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"作成者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"鄧, 文琪","creatorNameLang":"ja"},{"creatorName":"トウ, ブンキ","creatorNameLang":"ja-Kana"},{"creatorName":"Deng, Wenqi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"884","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-04-04"}],"filename":"kou_950.pdf","filesize":[{"value":"252.8 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"論文内容要旨・審査結果要旨","objectType":"abstract","url":"https://osaka-dent.repo.nii.ac.jp/record/358/files/kou_950.pdf"},"version_id":"de8e2db6-52c5-4739-b13b-957b321321ac"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-03-01"}],"filename":"kou_950_fulltxt.pdf","filesize":[{"value":"4.8 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"学位論文","objectType":"fulltext","url":"https://osaka-dent.repo.nii.ac.jp/record/358/files/kou_950_fulltxt.pdf"},"version_id":"f6e76a98-9284-465b-bfe8-0826fbbe4506"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Dedifferentiated fat cell","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cellular senescence","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Senescence-associated secretory phenotypes","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Senescence-associated secretory phenotypes in rat-derived dedifferentiated fat cells with replicative senescence","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Senescence-associated secretory phenotypes in rat-derived dedifferentiated fat cells with replicative senescence","subitem_title_language":"en"},{"subitem_title":"複製老化したラット由来脱分化脂肪細胞における老化関連分泌形質","subitem_title_language":"ja"}]},"item_type_id":"10006","owner":"16","path":["60"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-04-04"},"publish_date":"2023-04-04","publish_status":"0","recid":"358","relation_version_is_last":true,"title":["Senescence-associated secretory phenotypes in rat-derived dedifferentiated fat cells with replicative senescence"],"weko_creator_id":"16","weko_shared_id":-1},"updated":"2024-03-13T03:54:51.997010+00:00"}