{"created":"2023-05-15T13:57:38.942935+00:00","id":359,"links":{},"metadata":{"_buckets":{"deposit":"4e6b065b-0c35-404c-bd64-acb94418f07f"},"_deposit":{"created_by":16,"id":"359","owners":[16],"pid":{"revision_id":0,"type":"depid","value":"359"},"status":"published"},"_oai":{"id":"oai:osaka-dent.repo.nii.ac.jp:00000359","sets":["1686642104765:1:57:60"]},"author_link":["886"],"control_number":"359","item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2023-03-03"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"大阪歯科大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Osaka Dental University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"34408","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）","subitem_degreename_language":"ja"}]},"item_10006_description_7":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Although fluctuations in glucose concentration have been reported to regulate osteoblast differentiation, the effect on periodontal ligament cells is not clear. We investigated the effect of fluctuating glucose concentrations on the cellular functions of periodontal ligament cells (PDLCs). Variations in glucose concentration were examined in four ways: a group was incubated in 100 mg/dL glucose for 14 days; a group was incubated in 100 mg/dL glucose for 7 days, the solution was replaced with 0 mg/dL glucose, and the group was incubated for another 7 days; a group was incubated in 0 mg/dL glucose for 7 days, the solution was replaced with 100 mg/dL glucose, and the group was incubated for another 7 days; and a group was incubated in 0 mg/dL glucose for 14 days. We evaluated the osteogenic differentiation capacity by alkaline phosphatase (ALP) activity, ALP staining, calcium deposition and alizarin red staining after 14 days of culturing. We found that the osteogenic differentiation of PDLCs was enhanced in the presence of glucose, suggesting that it regulates the differentiation of PDLCs, especially in the early stage of differentiation.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第951号"}]},"item_10006_relation_14":{"attribute_name":"関連情報","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.18905/jodu.57.1_25","subitem_relation_type_select":"DOI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"Journal of Osaka Dental University. 2023, 57(1), p. 25-29."}]}]},"item_10006_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2023 The Author(s)","subitem_rights_language":"en"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"作成者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"鄧, 信","creatorNameLang":"ja"},{"creatorName":"デン, シン","creatorNameLang":"ja-Kana"},{"creatorName":"Deng, Xin","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"886","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-04-04"}],"filename":"kou_951.pdf","filesize":[{"value":"194.6 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"論文内容要旨・審査結果要旨","objectType":"abstract","url":"https://osaka-dent.repo.nii.ac.jp/record/359/files/kou_951.pdf"},"version_id":"5c6e714d-725e-451e-b813-8078b00fd213"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-03-01"}],"filename":"kou_951_fulltxt.pdf","filesize":[{"value":"812 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"学位論文","objectType":"fulltext","url":"https://osaka-dent.repo.nii.ac.jp/record/359/files/kou_951_fulltxt.pdf"},"version_id":"06ab9ca7-2cba-463f-ace2-db144b057350"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Periodontal ligament cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Glucose","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Osteogenic differentiation","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Effect of fluctuating glucose concentration on osteogenic differentiation of periodontal ligament cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effect of fluctuating glucose concentration on osteogenic differentiation of periodontal ligament cells","subitem_title_language":"en"},{"subitem_title":"グルコース濃度の変動が歯根膜細胞の骨芽細胞分化に及ぼす影響","subitem_title_language":"ja"}]},"item_type_id":"10006","owner":"16","path":["60"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-04-04"},"publish_date":"2023-04-04","publish_status":"0","recid":"359","relation_version_is_last":true,"title":["Effect of fluctuating glucose concentration on osteogenic differentiation of periodontal ligament cells"],"weko_creator_id":"16","weko_shared_id":-1},"updated":"2024-03-13T03:54:51.671782+00:00"}