{"created":"2023-05-15T13:57:39.030206+00:00","id":361,"links":{},"metadata":{"_buckets":{"deposit":"74f45c5e-9d70-4373-98a8-6ae7456ddc4c"},"_deposit":{"created_by":16,"id":"361","owners":[16],"pid":{"revision_id":0,"type":"depid","value":"361"},"status":"published"},"_oai":{"id":"oai:osaka-dent.repo.nii.ac.jp:00000361","sets":["1686642104765:1:57:60"]},"author_link":["890"],"control_number":"361","item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2023-03-03"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"大阪歯科大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Osaka Dental University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"34408","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）","subitem_degreename_language":"ja"}]},"item_10006_description_7":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Understanding the effect of smoking on oral pathologies at the molecular and cellular level is required for the stable progress of oral medicine. In the present study, we investigated the effect of tobacco smoke components (TSCs) and mechanical stimulation on the senescence of periodontal ligament cells. We cultured human periodontal ligament fibroblasts (HPdLFs) for different durations that were exposed to TSCs collected by our own original procedures. Proliferative activity and cellular senescence after TSC treatment was examined at different points in time. Our results demonstrated that HPdLFs continuously treated with TSCs exhibited characteristics of senescence. Moreover, there was an increased expression of the senescence-related gene when the senescent HPdLFs were cultured with a stretching stimulation. This result clearly suggests that stretching stimulation aggravates cellular senescence.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第953号"}]},"item_10006_relation_14":{"attribute_name":"関連情報","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.18905/jodu.57.1_47","subitem_relation_type_select":"DOI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"Journal of Osaka Dental University. 2023, 57(1), p. 47-53."}]}]},"item_10006_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2023 The Author(s)","subitem_rights_language":"en"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"作成者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"趙, 明","creatorNameLang":"ja"},{"creatorName":"チョウ, メイ","creatorNameLang":"ja-Kana"},{"creatorName":"Zhao, Ming","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"890","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-04-04"}],"filename":"kou_953.pdf","filesize":[{"value":"212.7 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"論文内容要旨・審査結果要旨","objectType":"abstract","url":"https://osaka-dent.repo.nii.ac.jp/record/361/files/kou_953.pdf"},"version_id":"8fc364e5-f746-4f26-ac70-5cfbc4357fd0"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-03-01"}],"filename":"kou_953_fulltxt.pdf","filesize":[{"value":"470 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"学位論文","objectType":"fulltext","url":"https://osaka-dent.repo.nii.ac.jp/record/361/files/kou_953_fulltxt.pdf"},"version_id":"27cabcc3-0286-4764-80d3-646e2a32cb25"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Cellular senescence","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Human periodontal fibroblasts","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Tobacco smoke components","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Stretching stimulation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"In vitro evaluation","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Aggravation of cellular senescence in human periodontal fibroblasts cultured with tobacco smoke components by stretching stimulation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Aggravation of cellular senescence in human periodontal fibroblasts cultured with tobacco smoke components by stretching stimulation","subitem_title_language":"en"},{"subitem_title":"タバコ煙成分で培養したヒト歯根膜線維芽細胞の伸展刺激による細胞老化の増悪化","subitem_title_language":"ja"}]},"item_type_id":"10006","owner":"16","path":["60"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-04-04"},"publish_date":"2023-04-04","publish_status":"0","recid":"361","relation_version_is_last":true,"title":["Aggravation of cellular senescence in human periodontal fibroblasts cultured with tobacco smoke components by stretching stimulation"],"weko_creator_id":"16","weko_shared_id":-1},"updated":"2024-03-13T03:54:50.945917+00:00"}