{"created":"2023-05-15T13:57:39.544430+00:00","id":370,"links":{},"metadata":{"_buckets":{"deposit":"ecce726e-e530-4039-ab71-e9c0a309eb08"},"_deposit":{"created_by":16,"id":"370","owners":[16],"pid":{"revision_id":0,"type":"depid","value":"370"},"status":"published"},"_oai":{"id":"oai:osaka-dent.repo.nii.ac.jp:00000370","sets":["1686642104765:1:57:60"]},"author_link":["908"],"control_number":"370","item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2023-03-03"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"大阪歯科大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Osaka Dental University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"34408","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）","subitem_degreename_language":"ja"}]},"item_10006_description_7":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Peri-implantitis is a disease that causes the detachment of orthodontic mini-implants.\nRecently, stress-induced senescent cells have been reported to be involved in various inflammatory diseases. Senescent cell-eliminating drugs, termed “senolytics”, can improve the symptoms of such diseases. However, the relationship between peri-implantitis and senescent cells remains unclear. In this study, we evaluated the presence of senescent cells in a rat peri-implantitis model developed with a gum ring. The effect on bone resorption and implant loss was also investigated with and without senolytics (Dasatinib and Quercetin). The number of senescence markers (p19, p21, and p16) was found to increase, and implant detachment occurred in 24 days. After the administration of senolytics, the number of senescence markers decreased and implant detachment was inhibited. This study suggests that senescent cells aggravate peri-implantitis and senolytic administration latently reduces implant loss by inhibiting senescence-related mechanisms.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第962号"}]},"item_10006_relation_14":{"attribute_name":"関連情報","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3390/ijms24032507","subitem_relation_type_select":"DOI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"International Journal of Molecular Sciences. 2023, 24(3), 2507."}]}]},"item_10006_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2023 The Author(s)","subitem_rights_language":"en"},{"subitem_rights":"Creative Commons Attribution 4.0 International","subitem_rights_language":"en","subitem_rights_resource":"https://creativecommons.org/licenses/by/4.0/"}]},"item_1696310207136":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"作成者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"楊, 妞馨","creatorNameLang":"ja"},{"creatorName":"ヨウ, ニュウシン","creatorNameLang":"ja-Kana"},{"creatorName":"Yang, Niuxin","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"908","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-04-04"}],"filename":"kou_962.pdf","filesize":[{"value":"261.6 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"論文内容要旨・審査結果要旨","objectType":"abstract","url":"https://osaka-dent.repo.nii.ac.jp/record/370/files/kou_962.pdf"},"version_id":"c85bc0f7-9dbd-4200-a4a5-5157fcc41ff7"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-03-01"}],"filename":"kou_962_fulltxt.pdf","filesize":[{"value":"5.5 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"学位論文","objectType":"fulltext","url":"https://osaka-dent.repo.nii.ac.jp/record/370/files/kou_962_fulltxt.pdf"},"version_id":"d3396d3d-a481-479a-9bd7-aa822b36a398"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"orthodontics","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"mini-implant","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"peri-implantitis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"senescence","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"senolytics","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Dasatinib","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Quersetin","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Identification of Senescent Cells in Peri-implantitis and Prevention of Mini-implant Loss Using Senolytics","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Identification of Senescent Cells in Peri-implantitis and Prevention of Mini-implant Loss Using Senolytics","subitem_title_language":"en"},{"subitem_title":"インプラント周囲炎における老化細胞の同定とセノリティクスによるミニインプラント脱落の防止","subitem_title_language":"ja"}]},"item_type_id":"10006","owner":"16","path":["60"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-04-04"},"publish_date":"2023-04-04","publish_status":"0","recid":"370","relation_version_is_last":true,"title":["Identification of Senescent Cells in Peri-implantitis and Prevention of Mini-implant Loss Using Senolytics"],"weko_creator_id":"16","weko_shared_id":-1},"updated":"2024-03-13T03:54:47.947928+00:00"}