{"created":"2023-05-15T13:57:39.589945+00:00","id":371,"links":{},"metadata":{"_buckets":{"deposit":"3a303875-829f-486e-9057-68651bf55838"},"_deposit":{"created_by":16,"id":"371","owners":[16],"pid":{"revision_id":0,"type":"depid","value":"371"},"status":"published"},"_oai":{"id":"oai:osaka-dent.repo.nii.ac.jp:00000371","sets":["1686642104765:1:57:60"]},"author_link":["910"],"control_number":"371","item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2023-03-03"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"大阪歯科大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Osaka Dental University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"34408","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）","subitem_degreename_language":"ja"}]},"item_10006_description_7":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"In the current World Health Organization (WHO) classification, oral epithelial dysplasia (OED) is classified using a two- or three-grade system. However, no useful auxiliary diagnostic method for determining the OED grade of specimens by this system has yet been established. In this study, specimens of not only OED, but also epithelial hyperplasia (Hp) and oral squamous cell carcinoma (OSCC) were examined immunohistochemically to investigate expression levels/rates of various antibodies. Six specimens of Hp, 13 of mild epithelial dysplasia (MiD), 11 of moderate epithelial dysplasia (MoD), 11 of severe epithelial dysplasia (SD), and 9 of OSCC obtained from the First Department of Oral and Maxillofacial Surgery at Osaka Dental University Hospital were examined immunohistochemically to determine the expression levels of CK13, CK17, CK19, Ki-67, p53, p63, p21, p27 and cyclin D1. The dysplasia grade was negatively correlated with expression of CK13 and CK17. As the dysplasia grade increased, expression rates of Ki-67, p53, p63, p21 and cyclin D1 increased, while the expression rate of p27 decreased. The expression rate of Ki-67 differed significantly between SD and OSCC, as did the expression of p53 between MoD and SD as well as between SD and OSCC. The expression rate of p63 differed significantly between MiD and MoD as well as between MoD and SD, as did the expression rate of p27 between SD and OSCC (p < 0.05). These results suggest that not only CK13, CK17, Ki-67 and p53, but also p63, p21, p27 and cyclin D1 may be linked to dysplasia. The results also suggest that calculation of Ki-67, p53, p63 and p27 expression rates could be used for OED grading and auxiliary diagnosis of OSCC.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第963号"}]},"item_10006_relation_14":{"attribute_name":"関連情報","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.18905/jodu.57.1_107","subitem_relation_type_select":"DOI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"Journal of Osaka Dental University. 2023, 57(1), p. 107-117."}]}]},"item_10006_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2023 The Author(s)","subitem_rights_language":"en"}]},"item_1696310207136":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"作成者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"北吉, 麻理奈","creatorNameLang":"ja"},{"creatorName":"キタヨシ, マリナ","creatorNameLang":"ja-Kana"},{"creatorName":"Kitayoshi, Marina","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-04-04"}],"filename":"kou_963.pdf","filesize":[{"value":"247.6 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"論文内容要旨・審査結果要旨","objectType":"abstract","url":"https://osaka-dent.repo.nii.ac.jp/record/371/files/kou_963.pdf"},"version_id":"605860f5-95ff-4bb1-8c01-7169de973b50"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-03-01"}],"filename":"kou_963_fulltxt.pdf","filesize":[{"value":"760 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"学位論文","objectType":"fulltext","url":"https://osaka-dent.repo.nii.ac.jp/record/371/files/kou_963_fulltxt.pdf"},"version_id":"b35c58cd-8bb0-4893-a556-a68a2ae33b19"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Oral epithelial dysplasia","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Ki-67","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"p53","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"p63","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"p27","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Immunohistochemical study of CK13, CK17, CK19, Ki-67, p53, p63, p21, p27 and Cyclin D1 in oral epithelial dysplasia","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Immunohistochemical study of CK13, CK17, CK19, Ki-67, p53, p63, p21, p27 and Cyclin D1 in oral epithelial dysplasia","subitem_title_language":"en"},{"subitem_title":"口腔粘膜の上皮性異形成におけるCK13, CK17, CK19, Ki 67, p53, p63, p21, p27 およびCyclin D1に関する免疫組織化学的検討","subitem_title_language":"ja"}]},"item_type_id":"10006","owner":"16","path":["60"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-04-04"},"publish_date":"2023-04-04","publish_status":"0","recid":"371","relation_version_is_last":true,"title":["Immunohistochemical study of CK13, CK17, CK19, Ki-67, p53, p63, p21, p27 and Cyclin D1 in oral epithelial dysplasia"],"weko_creator_id":"16","weko_shared_id":-1},"updated":"2024-03-13T03:54:47.621625+00:00"}