{"created":"2023-05-15T13:57:39.903511+00:00","id":378,"links":{},"metadata":{"_buckets":{"deposit":"8b241750-9480-4544-a784-c526706f6c42"},"_deposit":{"created_by":16,"id":"378","owners":[16],"pid":{"revision_id":0,"type":"depid","value":"378"},"status":"published"},"_oai":{"id":"oai:osaka-dent.repo.nii.ac.jp:00000378","sets":["1686642104765:1:57:60"]},"author_link":["924"],"control_number":"378","item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2023-03-03"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"大阪歯科大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Osaka Dental University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"34408","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）","subitem_degreename_language":"ja"}]},"item_10006_description_7":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Composite scaffolds obtained by the combination of biodegradable porous scaffolds and hydroxyapatite with bone regeneration potential are feasible materials for bone tissue engineering. However, most composite scaffolds have been fabricated by complicated procedures or under thermally harsh conditions. We have previously demonstrated that hydroxyapatite coating onto various substrates under a thermally mild condition was achieved by erbium-doped yttrium aluminum garnet (Er: YAG) pulsed laser deposition (PLD). The purpose of this study was to prepare a polycaprolactone (PCL) porous scaffold coated with the hydroxyapatite by the Er: YAG-PLD method. Hydroxyapatite coating by the Er: YAG-PLD method was confirmed by morphology, crystallographic analysis, and surface chemical characterization studies. When cultured on PCL porous scaffold coated with hydroxyapatite, rat bone marrow-derived mesenchymal stem cells adhered, spread, and proliferated well. The micro-CT and staining analyses after the implantation of scaffold into the critical-sized calvaria bone defect in rats indicate that PCL porous scaffold coated with hydroxyapatite demonstrates accelerated and widespread bone formation. In conclusion, PCL porous scaffold coated with hydroxyapatite obtained by the Er: YAG-PLD method is a promising material in bone tissue engineering.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第970号"}]},"item_10006_relation_14":{"attribute_name":"関連情報","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3390/ijms23169048","subitem_relation_type_select":"DOI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"International Journal of Molecular Sciences. 2022, 23(16), 9048."}]}]},"item_10006_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2023 The Author(s)","subitem_rights_language":"en"},{"subitem_rights":"Creative Commons Attribution 4.0 International","subitem_rights_language":"en","subitem_rights_resource":"https://creativecommons.org/licenses/by/4.0/"}]},"item_1696310207136":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"作成者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"張, 葉","creatorNameLang":"ja"},{"creatorName":"チョウ, イ","creatorNameLang":"ja-Kana"},{"creatorName":"Zhang, Ye","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"924","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-04-05"}],"filename":"kou_970.pdf","filesize":[{"value":"244.7 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"論文内容要旨・審査結果要旨","objectType":"abstract","url":"https://osaka-dent.repo.nii.ac.jp/record/378/files/kou_970.pdf"},"version_id":"c8c73329-b471-416c-b8d1-4debde4bfaf9"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-03-01"}],"filename":"kou_970_fulltxt.pdf","filesize":[{"value":"5.4 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"学位論文","objectType":"fulltext","url":"https://osaka-dent.repo.nii.ac.jp/record/378/files/kou_970_fulltxt.pdf"},"version_id":"1a0adfe9-b032-465d-8103-1a726ac5ddee"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Er: YAG laser","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"bone formation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"hydroxyapatite coating","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"polycaprolactone","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"porous scaffold","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"pulsed laser deposition","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Effect of Hydroxyapatite Coating by Er: YAG Pulsed Laser Deposition on the Bone Formation Efficacy by Polycaprolactone Porous Scaffold","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effect of Hydroxyapatite Coating by Er: YAG Pulsed Laser Deposition on the Bone Formation Efficacy by Polycaprolactone Porous Scaffold","subitem_title_language":"en"},{"subitem_title":"ポリカプロラクトン多孔質足場による骨形成効果に及ぼすEr: YAGパルスレーザー堆積法によるハイドロキシアパタイトコーティングの影響","subitem_title_language":"ja"}]},"item_type_id":"10006","owner":"16","path":["60"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-04-05"},"publish_date":"2023-04-05","publish_status":"0","recid":"378","relation_version_is_last":true,"title":["Effect of Hydroxyapatite Coating by Er: YAG Pulsed Laser Deposition on the Bone Formation Efficacy by Polycaprolactone Porous Scaffold"],"weko_creator_id":"16","weko_shared_id":-1},"updated":"2024-03-13T03:54:45.596463+00:00"}