@phdthesis{oai:osaka-dent.repo.nii.ac.jp:00000056,
 author = {林, 寛 and HAYASHI, Hiroshi},
 month = {2016-08-01, 2016-08-01},
 note = {In Orthodontic therapy, osteoclast precursors such as monocytes and macrophages migrate          from vessels into the periodontium and then differentiate into osteoclasts, causing bone          resorption. Focal adhesion kinase (FAK) is a 125-kDa non-receptor type tyrosine kinase          that localizes to focal adhesions. FAK is involved in osteoclastic bone resorption.          Vascular cell adhesion molecule-1 (VCAM -1) is bound to VLA-4(very late antigen-4) which          is kind of the α<sub>4</sub> β1-integrin, and recruits monocytic osteoclast progenitors          and elevates local osteoclast activity.In our present study we focused on VCAM-1 /α<sub>4</sub> integrin-mediated the          differentiation into osteoclasts and found that this type of the differentiation was          mediated through FAK. RAW267.4 expressed both α<sub>4</sub> integrins, and it was reported          that expression of α<sub>4</sub> integrin and its counterreceptor, VCAM-1, was not          enhanced in response to receptor activator of NF-B ligand (RANKL). Neutralizing antibodies          against integrin α4 effectively inhibit the differentiation into osteoclasts and          phosphorylation of FAK. These findings establish VCAM-1 regulate the differentiation into          osteoclasts in bone.},
 school = {大阪歯科大学},
 title = {Effect of VCAM-1 on the Differentiation into Osteoclast},
 year = {},
 yomi = {ハヤシ, ヒロシ}
}