{"created":"2023-05-15T13:57:22.683237+00:00","id":56,"links":{},"metadata":{"_buckets":{"deposit":"c222ecf2-5bc3-4bf5-b49d-aac86f690cb2"},"_deposit":{"created_by":15,"id":"56","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"56"},"status":"published"},"_oai":{"id":"oai:osaka-dent.repo.nii.ac.jp:00000056","sets":["1686642104765:1:7:10"]},"author_link":["208","207"],"item_10006_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"破骨細胞分化に及ぼすVCAM-1の影響"}]},"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2014-03-07"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"大阪歯科大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"34408","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）"}]},"item_10006_description_10":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_description":"2013","subitem_description_type":"Other"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In Orthodontic therapy, osteoclast precursors such as monocytes and macrophages migrate          from vessels into the periodontium and then differentiate into osteoclasts, causing bone          resorption. Focal adhesion kinase (FAK) is a 125-kDa non-receptor type tyrosine kinase          that localizes to focal adhesions. FAK is involved in osteoclastic bone resorption.          Vascular cell adhesion molecule-1 (VCAM -1) is bound to VLA-4(very late antigen-4) which          is kind of the α<sub>4</sub> β1-integrin, and recruits monocytic osteoclast progenitors          and elevates local osteoclast activity.In our present study we focused on VCAM-1 /α<sub>4</sub> integrin-mediated the          differentiation into osteoclasts and found that this type of the differentiation was          mediated through FAK. RAW267.4 expressed both α<sub>4</sub> integrins, and it was reported          that expression of α<sub>4</sub> integrin and its counterreceptor, VCAM-1, was not          enhanced in response to receptor activator of NF-B ligand (RANKL). Neutralizing antibodies          against integrin α4 effectively inhibit the differentiation into osteoclasts and          phosphorylation of FAK. These findings establish VCAM-1 regulate the differentiation into          osteoclasts in bone.","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第733号"}]},"item_10006_publisher_5":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"Japanese Association of Regenerative Dentistry"}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"林, 寛"},{"creatorName":"ハヤシ, ヒロシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"HAYASHI, Hiroshi","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-08-01"}],"displaytype":"detail","filename":"kou_733_txt..pdf","filesize":[{"value":"671.7 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"学位論文","url":"https://osaka-dent.repo.nii.ac.jp/record/56/files/kou_733_txt..pdf"},"version_id":"33a93c0b-fc9b-49c8-9b5c-e57a71668818"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-08-01"}],"displaytype":"detail","filename":"kou_733.pdf","filesize":[{"value":"228.7 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"論文内容要旨・審査結果要旨","url":"https://osaka-dent.repo.nii.ac.jp/record/56/files/kou_733.pdf"},"version_id":"7639eaa3-0c02-45f9-bbe2-c8bdd4491ae0"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"osteoclast","subitem_subject_scheme":"Other"},{"subitem_subject":"FAK","subitem_subject_scheme":"Other"},{"subitem_subject":"VCAM-1","subitem_subject_scheme":"Other"},{"subitem_subject":"RANKL","subitem_subject_scheme":"Other"},{"subitem_subject":"osteoclast","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"FAK","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"VCAM-1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"RANKL","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Effect of VCAM-1 on the Differentiation into Osteoclast","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effect of VCAM-1 on the Differentiation into Osteoclast"}]},"item_type_id":"10006","owner":"15","path":["10"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-08-01"},"publish_date":"2016-08-01","publish_status":"0","recid":"56","relation_version_is_last":true,"title":["Effect of VCAM-1 on the Differentiation into Osteoclast"],"weko_creator_id":"15","weko_shared_id":15},"updated":"2023-05-15T14:08:39.407237+00:00"}