{"created":"2023-05-15T13:57:23.194652+00:00","id":66,"links":{},"metadata":{"_buckets":{"deposit":"be424c86-a619-4729-99ec-42b1686f4993"},"_deposit":{"created_by":15,"id":"66","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"66"},"status":"published"},"_oai":{"id":"oai:osaka-dent.repo.nii.ac.jp:00000066","sets":["1686642104765:1:7:11"]},"author_link":["262","261"],"item_10006_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"2型糖尿病モデルラットにおける口蓋粘膜の形態学的研究"}]},"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2013-06-26"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"大阪歯科大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"34408","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）"}]},"item_10006_description_10":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_description":"2013","subitem_description_type":"Other"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We studied morphological differences in the palatine mucosa of two kinds of rats : the spontaneous type 2 diabetes mellitus (DM) rat (n=6) and the normal Wistar rat (n=6). Image analyses, performed on light micrographs of hematoxylin-eosin stained specimens, were used to compare the thickness of the keratinized, granular, prickle and basal layers in the mucosal epithelium. Further, the cell population of the granular and prickle layers and the thickness of the connective tissue beneath the mucosal epithelium were examined. The diameter of the capillaries in the palatine mucosa was determined by image analysis of scanning electron micrographs of microvascular corrosion cast specimens. We found that the keratinized and granular layers were significantly thicker in DM than in normal rats (p<0.01 ; both layers). Moreover, the cell population of the granular layer was significantly greater in DM than in normal rats (p<0.01). In contrast, the thickness of the connective tissue beneath the mucosal epithelium, and the diameter of the capillaries were significantly smaller in the DM than in normal rats (p<0.01). Our results indicate that hyperglycemia associated with type 2 DM causes hypertrophy of the keratinized and granular layers in the mucosal epithelium, atrophy of connective tissue beneath the mucosal epithelium, and microangiopathy of the capillaries of the palatine mucosa in the DM rat.","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"乙第1577号"}]},"item_10006_publisher_5":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"大阪歯科学会"}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"赤井, 啓祐"},{"creatorName":"アカイ, ケイスケ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Akai, Keisuke","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-08-01"}],"displaytype":"detail","filename":"JODU 47-2pp185-194Akai.pdf","filesize":[{"value":"578.3 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"学位論文","url":"https://osaka-dent.repo.nii.ac.jp/record/66/files/JODU 47-2pp185-194Akai.pdf"},"version_id":"9f83d23a-7ae8-4091-80ef-dc7ec3c7c332"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-08-01"}],"displaytype":"detail","filename":"otu_1577.pdf","filesize":[{"value":"233.2 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"論文内容要旨・審査結果要旨","url":"https://osaka-dent.repo.nii.ac.jp/record/66/files/otu_1577.pdf"},"version_id":"a0b1ebd2-ecab-4452-ada7-3d78c72b03b2"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Type 2 diabetes mellitus","subitem_subject_scheme":"Other"},{"subitem_subject":"Palatine mucosa","subitem_subject_scheme":"Other"},{"subitem_subject":"Microvascular corrosion cast","subitem_subject_scheme":"Other"},{"subitem_subject":"GK rats","subitem_subject_scheme":"Other"},{"subitem_subject":"Type 2 diabetes mellitus","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Palatine mucosa","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Microvascular corrosion cast","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"GK rats","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Morphological study of the palatine mucosa in the type 2 diabetes mellitus model rat","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Morphological study of the palatine mucosa in the type 2 diabetes mellitus model rat"}]},"item_type_id":"10006","owner":"15","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-08-01"},"publish_date":"2016-08-01","publish_status":"0","recid":"66","relation_version_is_last":true,"title":["Morphological study of the palatine mucosa in the type 2 diabetes mellitus model rat"],"weko_creator_id":"15","weko_shared_id":15},"updated":"2023-05-15T14:07:58.245230+00:00"}