| Item type |
学位論文 / Thesis or Dissertation(1) |
| 公開日 |
2016-08-01 |
| 本文言語 |
|
|
言語 |
eng |
| タイトル |
|
|
タイトル |
Expression patterns of CD66a and CD117 in the mouse submandibular gland |
| 著者 |
竹山, 旭
Takeyama, Akira
|
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Animals |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Carcinoembryonic Antigen |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Female |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Gene Expression Regulation |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Mice |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Proto-Oncogene Proteins c-kit |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Salivary Ducts |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Submandibular Gland |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_db06 |
|
資源タイプ |
doctoral thesis |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
The epithelial tissue of the salivary gland consists of the acinar and ductal parts, the latter of which is further divided into the intercalated, striated and excretory duct segments and is the residential site for salivary stem/progenitor cells. In the present study, the expression patterns of two cell surface molecules, CD66a and CD117, were investigated in the adult mouse submandibular glands (SMG) by immunofluorescence microscopy. Combinations of the two molecules differentially marked several types of SMG epithelial cells, including acinar cells (CD66a-intense, CD117-negative), intercalated duct cells (CD66a-intense, CD117-positive), a subset of the striated and excretory duct cells (CD66a-weak, CD117-positive). Most of the CD117-positive ductal cells were negative for cytokeratin 5 and overlapped with the NKCC1-expressing cells. The CD117- and keratin 5-positive cells resided only in the excretory duct were suggested to correspond to the recently identified salivary stem cells. CD66a and CD117 may be useful markers to isolate several cell types consisting of SMG epithelium and to analyze their molecular and cellular nature. Our data also suggest that CD117-expressing epithelial cells of the gland include at least two distinct populations of the stem/progenitor cells. |
| 学位名 |
|
|
学位名 |
博士（歯学） |
| 学位授与機関 |
|
|
|
学位授与機関識別子Scheme |
kakenhi |
|
|
学位授与機関識別子 |
34408 |
|
|
学位授与機関名 |
大阪歯科大学 |
| 学位授与年月日 |
|
|
学位授与年月日 |
2015-03-06 |
| 学位授与番号 |
|
|
学位授与番号 |
甲第761号 |
学位論文 (5.0 MB)
