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Coordinated effect of IL-17A and IL-27 on osteoclast differentiation of RANKL-stimulated RAW264.7 cells
https://osaka-dent.repo.nii.ac.jp/records/12
https://osaka-dent.repo.nii.ac.jp/records/12e402c831-2de5-4127-a946-16fe06a038ce
| 名前 / ファイル | ライセンス | アクション |
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学位論文 (259.6 kB)
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論文内容要旨・審査結果要旨 (190.3 kB)
Restricted Access
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||||||||
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| 公開日 | 2016-08-01 | |||||||||||
| 本文言語 | ||||||||||||
| 言語 | eng | |||||||||||
| タイトル | ||||||||||||
| タイトル | Coordinated effect of IL-17A and IL-27 on osteoclast differentiation of RANKL-stimulated RAW264.7 cells | |||||||||||
| 著者 |
⼤橋, 百加
× ⼤橋, 百加
× Ohashi, Momoka
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| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Interleukin-17A (IL-17A) | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Interleukin-27 (IL-27) | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Osteoclast differentiation | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||||||
| 資源タイプ | doctoral thesis | |||||||||||
| アクセス権 | ||||||||||||
| アクセス権 | open access | |||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||
| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | Orthodontic tooth movement is based on the response of biological tissue to mechanical loading. On both the compressed side and tensile side, stress is loaded onto cells by means of physical stimulation that causes cells to produce various cytokines that are involved in the promotion or suppression of osteoclast formation. During orthodontic tooth movement, alveolar bone resorption at the area of compression occurs through osteoclastic activity. In this study, we confirmed the coordinated effect of IL-17A and IL-27 on receptor activator of nuclear factor kB ligand (RANKL)-induced osteoclastogenesis, using RAW264.7 cells as osteoclast precursors. High expression of IL-17RC and IL27-Rα was detected on RAW264.7 cells, and this expression was not altered by the stimulation of RANKL for 24 h. A coordinated effect of IL-17A and IL-27 suppressed osteoclast differentiation from RAW264.7 cells treated with RANKL without reduction of cell proliferation. Furthermore, the phosphorylation of c-Jun-N-terminal kinase (JNK) stimulated with RANKL was inhibited by the coordinated effect of IL-17A and IL-27. These data suggest the possibility that the coordinated effect of IL-17A and IL-27 inhibited the phosphorylation of JNK which is involved in the suppression of RANKL-induced osteoclast differentiation in RAW264.7 cells. Our findings provide new insights into the mechanisms of osteoclastogenesis. | |||||||||||
| 学位名 | ||||||||||||
| 学位名 | 博士（歯学） | |||||||||||
| 学位授与機関 | ||||||||||||
| 学位授与機関識別子Scheme | kakenhi | |||||||||||
| 学位授与機関識別子 | 34408 | |||||||||||
| 学位授与機関名 | 大阪歯科大学 | |||||||||||
| 学位授与年月日 | ||||||||||||
| 学位授与年月日 | 2015-03-06 | |||||||||||
| 学位授与番号 | ||||||||||||
| 学位授与番号 | 甲第747号 | |||||||||||
