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Study of infection and malignant transformation of human papillomavirus in oral squamous cell carcinoma
https://osaka-dent.repo.nii.ac.jp/records/168
https://osaka-dent.repo.nii.ac.jp/records/168fe62df10-5bff-4c28-ac9f-dc169ccc1bd7
| 名前 / ファイル | ライセンス | アクション |
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学位論文 (328.7 kB)
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論文内容要旨・審査結果要旨 (180.6 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||||||
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| 公開日 | 2017-04-19 | |||||||||
| 本文言語 | ||||||||||
| 言語 | eng | |||||||||
| タイトル | ||||||||||
| タイトル | Study of infection and malignant transformation of human papillomavirus in oral squamous cell carcinoma | |||||||||
| 著者 |
安田, 典泰
× 安田, 典泰
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| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||||
| 資源タイプ | doctoral thesis | |||||||||
| アクセス権 | ||||||||||
| アクセス権 | open access | |||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | Human papillomavirus (HPV) is associated with the onset of oral dysplasia and oral squamous cell carcinoma (OSCC). In this study, we examined p53, p16INK4a, HPV 16/18 E6, and HPV L1 in oral papilloma (OP), oral dysplasia (OD), and OSCC to clarify the relationship between HPV infection and malignant transformation. We used 11 samples of OP, 14 of low grade oral dysplasia, 10 of high grade oral dysplasia, 21 of well to moderately differentiated squamous cell carcinomas (W-MSCC), and 8 of poorly differentiated squamous cell carcinomas in oral lesions obtained from Osaka Dental University Hospital. We performed immunohistochemical staining to study the expression of HPV 16/18 E6, HPV L1, p53, and p16INK4a in each lesion. Marked expression of p16INK4a was seen in HPV 16/18 E6 positive W-MSCC, and marked expression of p53 was seen in HPV L1 positive OD. These results suggest that HPV may play an important role in the transformation of p53 and p16INK4a, and that p16INK4a is a possible marker of HPV infection. |
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| 学位名 | ||||||||||
| 学位名 | 博士（歯学） | |||||||||
| 学位授与機関 | ||||||||||
| 学位授与機関識別子Scheme | kakenhi | |||||||||
| 学位授与機関識別子 | 34408 | |||||||||
| 学位授与機関名 | 大阪歯科大学 | |||||||||
| 学位授与年月日 | ||||||||||
| 学位授与年月日 | 2017-03-10 | |||||||||
| 学位授与番号 | ||||||||||
| 学位授与番号 | 甲第810号 | |||||||||
