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Surface modification of porous alpha-tricalcium phosphate granules with heparin enhanced their early osteogenic capability in a rat calvarial defect model
https://osaka-dent.repo.nii.ac.jp/records/180
https://osaka-dent.repo.nii.ac.jp/records/180a1d7013f-6685-4df6-85d2-d55306aa12d1
| 名前 / ファイル | ライセンス | アクション |
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学位論文 (2.8 MB)
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論文内容要旨・審査結果要旨 (212.3 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-05-17 | |||||
| 本文言語 | ||||||
| 言語 | eng | |||||
| タイトル | ||||||
| タイトル | Surface modification of porous alpha-tricalcium phosphate granules with heparin enhanced their early osteogenic capability in a rat calvarial defect model | |||||
| 著者 |
武田, 吉裕
× 武田, 吉裕 |
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| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | heparin | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | calcium phosphate | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | α-tricalcium phosphate | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | critical size defects | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | surface modification | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
| 資源タイプ | doctoral thesis | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Heparin binds to and modulates various growth factors, potentially augmenting the bone-forming capability of biomaterials. Here, α-tricalcium phosphate (α-TCP) granules were modified with peptide containing the marine mussel-derived adhesive sequence, which reacts with α-TCP surface, and cationic sequence, which binds to heparin (α-Ph).α-Ph retained the α-TCP phase and intergranule spaces after the surface modification. The existence of heparin on α-Ph granules was confirmed using x-ray photoelectron spectroscopy. Granules of α-TCP and α-Ph were implanted into critical-size defects in rat calvaria for 4 weeks. Micro-computed tomography, histological evaluation, and Alcian blue staining revealed that α-Ph induced superior bone formation compared with α-TCP. Newly formed bone on α-Ph was preferentially in contact with the Alcian blue-stained surfaces of granules. These results suggested that heparinization enhanced the early osteogenic capacity of α-TCP, possibly by modulating the secretion of Alcian blue-stained extracellular matrixes. | |||||
| 学位名 | ||||||
| 学位名 | 博士（歯学） | |||||
| 学位授与機関 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 34408 | |||||
| 学位授与機関名 | 大阪歯科大学 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2018-03-09 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲第818号 | |||||
