WEKO3
アイテム
Bactericidal effect of performic acid on salivary bacteria
https://osaka-dent.repo.nii.ac.jp/records/183
https://osaka-dent.repo.nii.ac.jp/records/183879e422b-2a02-4a48-80b5-a5f72e26355e
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
学位論文 (270.5 kB)
|
|
|
|
論文内容要旨・審査結果要旨 (172.6 kB)
|
|
| Item type | 学位論文 / Thesis or Dissertation(1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2018-05-17 | |||||||||
| 本文言語 | ||||||||||
| 言語 | eng | |||||||||
| タイトル | ||||||||||
| タイトル | Bactericidal effect of performic acid on salivary bacteria | |||||||||
| 著者 |
森岡, 裕貴
× 森岡, 裕貴
|
|||||||||
| キーワード | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Performic acid｜Bactericidal activity｜Salivary bacteria | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||||
| 資源タイプ | doctoral thesis | |||||||||
| アクセス権 | ||||||||||
| アクセス権 | open access | |||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | Although heat-sensitive semi-critical medical devices (e.g., transnasal endoscopes) should undergo high-level disinfection between patients, these devices are often harmful to humans and the environment due to their residual toxicity caused by disinfectants. We analyzed the bactericidal activity against salivary bacteria of performic acid (PFA) which has strong antibacterial activity and has shown a consistent absence of genotoxic and mutagenic effects on human cells. Collected saliva samples were mixed with various concentrations of PFA. After incubation, bactericidal activity was assessed with colony-forming assays and quantification of ATP produced by metabolically active cells. Even for a 1-minute exposure, PFA showed a strong bactericidal effect against salivary bacteria, in which more than 99.9% and 67.1% of bacterial colonies were suppressed at 8×10-4% (w/v) and 8×10-6% (w/v) PFA, respectively. This effect was enhanced by prolonged incubation. Bacterial viability assay based on ATP measurement also showed concentration-dependent bactericidal effects of PFA. PFA showed comparatively strong antibacterial activity against salivary bacteria, even with short duration exposure. | |||||||||
| 学位名 | ||||||||||
| 学位名 | 博士（歯学） | |||||||||
| 学位授与機関 | ||||||||||
| 学位授与機関識別子Scheme | kakenhi | |||||||||
| 学位授与機関識別子 | 34408 | |||||||||
| 学位授与機関名 | 大阪歯科大学 | |||||||||
| 学位授与年月日 | ||||||||||
| 学位授与年月日 | 2018-03-09 | |||||||||
| 学位授与番号 | ||||||||||
| 学位授与番号 | 甲第821号 | |||||||||
