| Item type |
学位論文 / Thesis or Dissertation(1) |
| 公開日 |
2016-08-01 |
| 本文言語 |
|
|
言語 |
jpn |
| タイトル |
|
|
タイトル |
Bone response around titanium alloy implants in osteoporosis |
| 著者 |
加山, 智規
Kayama, Tomoki
|
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Implant |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Osteoporosis |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Osseointegration |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Implant |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Osteoporosis |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Osseointegration |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_db06 |
|
資源タイプ |
doctoral thesis |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Few studies have investigated bone healing properties of the extracted tooth socket in osteoporosis. We evaluated the bone's response to mandibular incisor extraction and titanium alloy screw placement in a rat model of osteoporosis both in vitro and in vivo. Ovariectomy (OVX) or a sham operation (control group) was performed at 9 weeks of age. For the in vitro study, alkaline phosphate activity at 7 and 14 days, osteocalcin production at 21 and 28 days, and calcium deposition at 21 and 28 days were measured on titanium alloy disks. For the in vivo study, animal body weights were measured every 3 weeks to observe changes. Titanium alloy screws were placed into the the mandibular incisor extraction sockets. At 3, 6 and 9 weeks post-insertion, histological analyses were performed. At all measured time points, cells of the control group showed significantly more alkaline phosphate activity, osteocalcin production, and calcium deposition than cells of the OVX group. Healing processes of the extraction socket after insertion of a titanium screw differed between the control and OVX groups. Histopathologically, ovariectomized rats showed a marked inhibition of the formation of new bone in the extraction socket. |
| 学位名 |
|
|
学位名 |
博士（歯学） |
| 学位授与機関 |
|
|
|
学位授与機関識別子Scheme |
kakenhi |
|
|
学位授与機関識別子 |
34408 |
|
|
学位授与機関名 |
大阪歯科大学 |
| 学位授与年月日 |
|
|
学位授与年月日 |
2015-03-06 |
| 学位授与番号 |
|
|
学位授与番号 |
甲第757号 |
学位論文 (413.2 kB)
