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口腔領域の囊胞性疾患におけるアメロジェニンの発現
https://osaka-dent.repo.nii.ac.jp/records/2000007
https://osaka-dent.repo.nii.ac.jp/records/200000765ee3375-e4ce-42aa-be75-7adbb255a1f2
| 名前 / ファイル | ライセンス | アクション |
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論文内容要旨・審査結果要旨 (219 KB)
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学位論文 (848 KB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||||||||
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| 公開日 | 2023-09-12 | |||||||||||
| 本文言語 | ||||||||||||
| 言語 | eng | |||||||||||
| タイトル | ||||||||||||
| タイトル | The expression of amelogenin in oral cystic lesions | |||||||||||
| 言語 | en | |||||||||||
| タイトル | ||||||||||||
| タイトル | 口腔領域の囊胞性疾患におけるアメロジェニンの発現 | |||||||||||
| 言語 | ja | |||||||||||
| 著者 |
殷, 傑
× 殷, 傑
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| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Immunohistochemical staining | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Synthetic oligopeptide | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Monoclonal antibody | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Odontogenic epithelium | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||||||
| 資源タイプ | doctoral thesis | |||||||||||
| アクセス権 | ||||||||||||
| アクセス権 | open access | |||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||
| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | Subcutaneous injection of enamel matrix derivative into rat back tissue results in the formation of eosinophilic round bodies (ERBs). When a large amount of ERBs are formed, they induce cartilage. Our previous studies have shown that ERB is a part of amelogenin exon-5. We therefore artificially created synthesised peptide (SP) with the same sequence as ERB. Subcutaneous injection of SP into rat back tissue induces bone and endochondral bone formation. Since amelogenin plays many important roles, we hypothesised that ERB, which is a part of amelogenin, may also play an important role. For this reason we produced a mouse monoclonal antibody (A-ERB) using SP, to investigate the function of ERB. In the present study, immunohistochemical staining with A-ERB was performed on oral cystic lesions in the expectation that A-ERB would react with odontogenic epithelium. We selected as test material seven human oral cystic lesions, the radicular cyst, dentigerous cyst, dermoid cyst, epidermoid cyst, orthokeratinised odontogenic cyst, odontogenic keratocyst, and unicystic ameloblastoma. They were sectioned and immunohistochemically stained using A-ERB. Although ERBs were expressed in the lining epithelium of dermoid cysts, they were not expressed in the epidermoid cysts. Although epidermis with cutaneous appendages expressed ERB, epidermis without cutaneous appendages did not. Dermoid and epidermoid cysts are now classified as the same lesion. However, the character of the lining epithelium of the two is different. Perhaps the two lesions should not be in the same category. | |||||||||||
| 言語 | en | |||||||||||
| 学位名 | ||||||||||||
| 言語 | ja | |||||||||||
| 学位名 | 博士（歯学） | |||||||||||
| 学位授与機関 | ||||||||||||
| 学位授与機関識別子Scheme | kakenhi | |||||||||||
| 学位授与機関識別子 | 34408 | |||||||||||
| 言語 | ja | |||||||||||
| 学位授与機関名 | 大阪歯科大学 | |||||||||||
| 言語 | en | |||||||||||
| 学位授与機関名 | Osaka Dental University | |||||||||||
| 学位授与年月日 | ||||||||||||
| 学位授与年月日 | 2023-06-28 | |||||||||||
| 学位授与番号 | ||||||||||||
| 学位授与番号 | 乙第1658号 | |||||||||||
| 権利 | ||||||||||||
| 言語 | en | |||||||||||
| 権利情報 | © 2023 The Author(s) | |||||||||||
| 関連情報 | ||||||||||||
| 識別子タイプ | DOI | |||||||||||
| 関連識別子 | https://doi.org/10.18905/jodu.57.1_137 | |||||||||||
| 関連情報 | ||||||||||||
| 関連名称 | Journal of Osaka Dental University. 2023, 57(1), p. 137-146. | |||||||||||
