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脳梗塞後段階的再灌流が再灌流障害におよぼす影響
https://osaka-dent.repo.nii.ac.jp/records/2000112
https://osaka-dent.repo.nii.ac.jp/records/20001127c30e3c1-825c-4443-ad93-ec9e3430c395
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
本文内容要旨・審査結果要旨 (210 KB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||||||||
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| 公開日 | 2024-06-01 | |||||||||||
| 本文言語 | ||||||||||||
| 言語 | eng | |||||||||||
| タイトル | ||||||||||||
| タイトル | Effects of stepwise reperfusion after cerebral infarction on reperfusion injury | |||||||||||
| 言語 | en | |||||||||||
| タイトル | ||||||||||||
| タイトル | 脳梗塞後段階的再灌流が再灌流障害におよぼす影響 | |||||||||||
| 言語 | ja | |||||||||||
| 著者 |
吉田, 啓太
× 吉田, 啓太
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| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | hyperperfusion | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | reperfusion injury | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | pericute | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||||||
| 資源タイプ | doctoral thesis | |||||||||||
| アクセス権 | ||||||||||||
| アクセス権 | metadata only access | |||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||||||||
| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | The present study aims to investigate the effect of mechanically avoiding hyperperfusion on reperfusion injury. Experiments were performed using a CB17-strain mouse cerebral ischemia model with excellent reproducibility of infarct foci. After occlusion of the left middle cerebral artery for 45 minutes under sevoflurane anesthesia, the experimental group was divided into two groups as follows: "full opening immediately after occlusion (Total reperfusion group)" and "full opening after 30 minutes of half opening (stepwise reperfusion group). In each group, brain sections were frozen after reflux fixation on the next day and after 2 and 3 days. Pericytes, neurons, glial cells, neural stem cell markers, and apoptosis markers were evaluated using immunohistochemistry staining. Three days later, we performed triphenyl tetrazolium chloride staining to check the expression of cerebral infarcts. We found no difference in the occurrence of cerebral infarction and neuronal loss in the cerebral cortex; however, in the total reperfusion group, pericyte damage and loss were more frequent in the area from the cerebral cortex to the striatum. Therefore, if blood flow after cerebral infarction of unknown onset can be restored gradually to reduce hyperperfusion immediately after recanalization, reperfusion injury can be reduced, and this may be beneficial for nerve regeneration. | |||||||||||
| 言語 | en | |||||||||||
| 学位名 | ||||||||||||
| 言語 | ja | |||||||||||
| 学位名 | 博士（歯学） | |||||||||||
| 学位授与機関 | ||||||||||||
| 学位授与機関識別子Scheme | kakenhi | |||||||||||
| 学位授与機関識別子 | 34408 | |||||||||||
| 言語 | ja | |||||||||||
| 学位授与機関名 | 大阪歯科大学 | |||||||||||
| 言語 | en | |||||||||||
| 学位授与機関名 | Osaka Dental University | |||||||||||
| 学位授与年月日 | ||||||||||||
| 学位授与年月日 | 2024-03-01 | |||||||||||
| 学位授与番号 | ||||||||||||
| 学位授与番号 | 甲第1000号 | |||||||||||
