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Effect of Flowable Composite Resin on Cell Viability of Balb/c 3T3 Cells
https://osaka-dent.repo.nii.ac.jp/records/2000216
https://osaka-dent.repo.nii.ac.jp/records/20002162d794fdb-9053-40a3-bbef-34ae8ff714a4
| 名前 / ファイル | ライセンス | アクション |
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論文内容要旨・審査結果要旨 (1.4 MB)
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学位論文 (1.7 MB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||||||||
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| 公開日 | 2025-04-25 | |||||||||||
| 本文言語 | ||||||||||||
| 言語 | eng | |||||||||||
| タイトル | ||||||||||||
| タイトル | Effect of Flowable Composite Resin on Cell Viability of Balb/c 3T3 Cells | |||||||||||
| 言語 | en | |||||||||||
| 著者 |
桝井, 悦子
× 桝井, 悦子
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| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | flowable composite resin | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | cell viability | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Balb/c 3T3 cells | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||||||
| 資源タイプ | doctoral thesis | |||||||||||
| アクセス権 | ||||||||||||
| アクセス権 | metadata only access | |||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||||||||
| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | The flowable composite resins have been routinely used in recent clinical den-tistry. However, few studies have investigated the biological influence of flowable composite resins commercially available in Japan. In this study, we compared cell viability among 5 products currently available in dental clinical practice. Using mouse-derived Balb/c 3T3 cells, DMEM containing 5% fetal calf serum was adopted as an assay medium. Initially, the flowable resins were dissolved in the assay medium in the presence of dimethyl sulfoxide (DMSO) be-fore photopoly-merization, and each solution was diluted multiple times to investigate cell viability. As a result, all products showed cell death at a dilution ratio of 2. At a dilution ratio of 4 or 8, there was a marked decrease in cell viability. At a dilution ratio of 16, Subsequently, cell viability tests after photopolymerization were performed. Sam-ples were irradiated with an LED-type light irradiator for 5 or 10 seconds, and cell viability was investigated using the three-dimensional culture method with colla-gen. Cell viability was evaluated using MTT assay. Cell viability in the 10-second irradiation group for all products was higher than in the 5-second irradiation group. Some products showed no significant difference in comparison with the negative control group. There was no relationship between the monomer composition or filler type of any product and cell viability. The results of this study showed that cell viability slightly differed among the 5 clinically available products. There was no product for which cell viability was particularly low. |
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| 言語 | en | |||||||||||
| 学位名 | ||||||||||||
| 言語 | ja | |||||||||||
| 学位名 | 博士（口腔科学） | |||||||||||
| 学位授与機関 | ||||||||||||
| 学位授与機関識別子Scheme | kakenhi | |||||||||||
| 学位授与機関識別子 | 34408 | |||||||||||
| 言語 | ja | |||||||||||
| 学位授与機関名 | 大阪歯科大学 | |||||||||||
| 言語 | en | |||||||||||
| 学位授与機関名 | Osaka Dental University | |||||||||||
| 学位授与年月日 | ||||||||||||
| 学位授与年月日 | 2025-03-13 | |||||||||||
| 学位授与番号 | ||||||||||||
| 学位授与番号 | 甲第9号 | |||||||||||
| 関連情報 | ||||||||||||
| 識別子タイプ | DOI | |||||||||||
| DOI | https://doi.org/10.11223/jarde.22.29 | |||||||||||
| 掲載情報 | Journal of Oral Tissue Engineering, 2024, 22(1), p. 29-36 | |||||||||||
