| Item type |
学位論文 / Thesis or Dissertation(1) |
| 公開日 |
2019-05-17 |
| 本文言語 |
|
|
言語 |
eng |
| タイトル |
|
|
タイトル |
In Vitro and In Vivo Osteogenic Activity of Titanium Implants Coated by Pulsed Laser Deposition with a Thin Film of Fluoridated Hydroxyapatite |
| 著者 |
陳, 路沅
Chen, Luyuan
|
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
fluoridated hydroxyapatite｜implant｜osteogenic activity｜pulsed laser deposition｜rat femur model |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_db06 |
|
資源タイプ |
doctoral thesis |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 抄録 |
|
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内容記述タイプ |
Abstract |
|
内容記述 |
To enhance biocompatibility, osteogenesis, and osseointegration, we coated titanium implants, by krypton fluoride (KrF) pulsed laser deposition, with a thin film of fluoridated hydroxyapatite (FHA). Coating was confirmed by scanning electron microscopy (SEM) and scanning probe microscopy (SPM), while physicochemical properties were evaluated by attenuated reflectance Fourier transform infrared spectroscopy (ATR-FTIR). Calcium deposition, osteocalcin production, and expression of osteoblast genes were significantly higher in rat bone marrow mesenchymal stem cells seeded on FHA-coated titanium than in cells seeded on uncoated titanium. Implantation into rat femurs also showed that the FHA-coated material had superior osteoinductive and osseointegration activity in comparison with that of traditional implants, as assessed by microcomputed tomography and histology. Thus, titanium coated with FHA holds promise as a dental implant material. |
| 学位名 |
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|
学位名 |
博士（歯学） |
| 学位授与機関 |
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|
|
学位授与機関識別子Scheme |
kakenhi |
|
|
学位授与機関識別子 |
34408 |
|
|
学位授与機関名 |
大阪歯科大学 |
| 学位授与年月日 |
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学位授与年月日 |
2019-03-08 |
| 学位授与番号 |
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|
学位授与番号 |
甲第854号 |
学位論文 (39.0 MB)
